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Trends and strategies to enhance triacylglycerols and high-value compounds in microalgae

2017-07Journal article Open Access
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dc.contributor.authorLisa Schueler, Lisa M. Schueler
dc.contributor.authorSchulze, Peter S.C.
dc.contributor.authorPereira, Hugo
dc.contributor.authorBarreira, Luísa
dc.contributor.authorLeon, Rosa
dc.contributor.authorJ. C. or Varela J. or Varela J.C.S., Varela
dc.date.accessioned2019-11-20T15:07:30Z
dc.date.available2019-11-20T15:07:30Z
dc.date.issued2017-07
dc.description.abstractMicroalgae are important sources of triacylglycerols (TAGs) and high-value compounds such as carotenoids and long-chain polyunsaturated fatty acids (LC-PUFAs). TAGs are feedstocks for biofuels or edible oils; carotenoids are used as pigments in the food and feed industries; and LC-PUFAs are beneficial for human health, being also key to the correct development of fish in aquaculture. Current trends in microalgal biotechnology propose the combined production of biofuels with high-value compounds to turn large-scale production of microalgal biomass into an economically feasible venture. As TAGs, carotenoids and LC-PUFAs are lipophilic biomolecules, they not only share biosynthetic precursors and storage sinks, but also their regulation often depends on common environmental stimuli. In general, stressful conditions favor carotenoid and TAGs biosynthesis, whereas the highest accumulation of LC-PUFAs is usually obtained under conditions promoting growth. However, there are known exceptions to these general rules, as a few species are able to accumulate LC-PUFAs under low light, low temperature or long-term stress conditions. Thus, future research on how microalgae sense, transduce and respond to environmental stress will be crucial to understand how the biosynthesis and storage of these lipophilic molecules are regulated. The use of high-throughput methods (e.g. fluorescent activated cell sorting) will provide an excellent opportunity to isolate triple-producers, i.e. microalgae able to accumulate high levels of LC-PUFAs, carotenoids and TAGs simultaneously. Comparative transcriptomics between wild type and tripleproducers could then be used to identify key gene products involved in the regulation of these biomolecules even in microalgal species not amenable to reverse genetics. This combined approach could be a major step towards a better understanding of the microalgal metabolism under different stress conditions. Moreover, the generation of triple-producers would be essential to raise the biomass value in a biorefinery setting and contribute to meet the world's rising demand for food, feed and energy.
dc.description.sponsorshipFoundation for Science and Technology (Portugal) through research programme [CCMAR/Multi/04326/2013]
dc.description.sponsorshipdoctoral research grants [SFRH/BD/105541/2014, SFRH/BD/115325/2016]
dc.description.sponsorshipSpanish Ministry of Economy and Competitiveness [AGL2016-74866-C3-02]
dc.description.sponsorshipCEIMAR
dc.description.sponsorshipNord University and Nordland County Government project Bioteknologi-en framtidsrettet noering
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.algal.2017.05.025
dc.identifier.issn2211-9264
dc.identifier.urihttp://hdl.handle.net/10400.1/13071
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectFatty-acid-composition
dc.subjectDiatom phaeodactylum-tricornutum
dc.subjectParietochloris-incisa trebuxiophyceae
dc.subjectType-2 diacylglycerol acyltransferase
dc.subjectOceanica Ccala 804
dc.subjectNitrogen starvation
dc.subjectChlamydomonas-reinhardtii
dc.subjectChlorella-zofingiensis
dc.subjectDunaliella-salina
dc.subjectMarine microalgae
dc.titleTrends and strategies to enhance triacylglycerols and high-value compounds in microalgae
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage273
oaire.citation.startPage263
oaire.citation.titleAlgal Research
oaire.citation.volume25
person.familyNameSchüler
person.familyNameSchulze
person.familyNamePereira
person.familyNameBarreira
person.familyNameVarela
person.givenNameLisa
person.givenNamePeter S.C.
person.givenNameHugo
person.givenNameLuísa
person.givenNameJoão
person.identifier282781
person.identifier.ciencia-idE01F-9B43-4F24
person.identifier.ciencia-idF41E-3B55-577C
person.identifier.ciencia-id331E-84FD-2F34
person.identifier.ciencia-id6D1A-17E5-1400
person.identifier.orcid0000-0003-0961-5397
person.identifier.orcid0000-0003-3777-8732
person.identifier.orcid0000-0002-1369-2099
person.identifier.orcid0000-0002-4077-855X
person.identifier.orcid0000-0003-3101-693X
person.identifier.ridE-9360-2015
person.identifier.ridM-4223-2013
person.identifier.scopus-author-id56244247100
person.identifier.scopus-author-id54080259900
person.identifier.scopus-author-id55741416000
rcaap.rightsopenAccess
rcaap.typearticle
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