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Tracking prostate carcinogenesis over time through urine proteome profiling in an animal model: an exploratory approach

2022-07-08Journal article Open Access
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dc.contributor.authorMoreira-Pais, Alexandra
dc.contributor.authorNogueira-Ferreira, Rita
dc.contributor.authorReis, Stephanie
dc.contributor.authorAveiro, Susana
dc.contributor.authorBarros, António
dc.contributor.authorMelo, Tânia
dc.contributor.authorMatos, Bárbara
dc.contributor.authorDuarte, José Alberto
dc.contributor.authorSeixas, Fernanda
dc.contributor.authorDomingues, Pedro
dc.contributor.authorAmado, Francisco
dc.contributor.authorFardilha, Margarida
dc.contributor.authorOliveira, Paula A.
dc.contributor.authorFerreira, Rita
dc.contributor.authorVitorino, Rui
dc.date.accessioned2022-07-27T09:20:15Z
dc.date.available2022-07-27T09:20:15Z
dc.date.issued2022-07-08
dc.date.updated2022-07-25T16:32:52Z
dc.description.abstractProstate cancer (PCa) is one of the most lethal diseases in men, which justifies the search for new diagnostic tools. The aim of the present study was to gain new insights into the progression of prostate carcinogenesis by analyzing the urine proteome. To this end, urine from healthy animals and animals with prostate adenocarcinoma was analyzed at two time points: 27 and 54 weeks. After 54 weeks, the incidence of pre-neoplastic and neoplastic lesions in the PCa animals was 100%. GeLC-MS/MS and subsequent bioinformatics analyses revealed several proteins involved in prostate carcinogenesis. Increased levels of retinol-binding protein 4 and decreased levels of cadherin-2 appear to be characteristic of early stages of the disease, whereas increased levels of enolase-1 and T-kininogen 2 and decreased levels of isocitrate dehydrogenase 2 describe more advanced stages. With increasing age, urinary levels of clusterin and corticosteroid-binding globulin increased and neprilysin levels decreased, all of which appear to play a role in prostate hyperplasia or carcinogenesis. The present exploratory analysis can be considered as a starting point for studies targeting specific human urine proteins for early detection of age-related maladaptive changes in the prostate that may lead to cancer.pt_PT
dc.description.sponsorshipCEECIND/03935/2021
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInternational Journal of Molecular Sciences 23 (14): 7560 (2022)pt_PT
dc.identifier.doi10.3390/ijms23147560pt_PT
dc.identifier.eissn1422-0067
dc.identifier.urihttp://hdl.handle.net/10400.1/18105
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationResearch Center in Physical Activity , Health and Leisure
dc.relationLaboratory for Integrative and Translational Research in Population Health
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationVeterinary and Animal Science Research Centre
dc.relationAveiro Institute of Biomedicine
dc.relationCentre for Environmental and Marine Studies
dc.relationHealth Research Network: From Lab to Community Health
dc.relationCardiovascular Research and Development Center
dc.relationCardiovascular Research and Development Center
dc.relationSarcopenia or Cachexia: how to explain muscle loss in aged subjects with an underlying chronic diseases
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAgingpt_PT
dc.subjectGeLC-MS/MSpt_PT
dc.subjectUrinary proteomicspt_PT
dc.subjectProstate adenocarcinomapt_PT
dc.subjectRetinol-binding protein 4pt_PT
dc.subjectCadherin-2pt_PT
dc.subjectEnolase-1pt_PT
dc.titleTracking prostate carcinogenesis over time through urine proteome profiling in an animal model: an exploratory approachpt_PT
dc.typejournal article
dspace.entity.typePublication
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oaire.awardTitleLaboratory for Integrative and Translational Research in Population Health
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitleVeterinary and Animal Science Research Centre
oaire.awardTitleAveiro Institute of Biomedicine
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleHealth Research Network: From Lab to Community Health
oaire.awardTitleCardiovascular Research and Development Center
oaire.awardTitleCardiovascular Research and Development Center
oaire.awardTitleSarcopenia or Cachexia: how to explain muscle loss in aged subjects with an underlying chronic diseases
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oaire.citation.issue14pt_PT
oaire.citation.startPage7560pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume23pt_PT
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person.familyNameAveiro
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rcaap.rightsopenAccesspt_PT
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