Repository logo
 
Publication

Antioxidant, antimicrobial, and bioactive potential of two new haloarchaeal strains isolated from Odiel Salterns (Southwest Spain)

2020-09Journal article Open access
Simple item page
dc.contributor.authorGómez-Villegas, Patricia
dc.contributor.authorVigara, Javier
dc.contributor.authorVila, Marta
dc.contributor.authorVarela, João
dc.contributor.authorBarreira, Luísa
dc.contributor.authorLéon, Rosa
dc.date.accessioned2020-11-11T17:48:55Z
dc.date.available2020-11-11T17:48:55Z
dc.date.issued2020-09
dc.description.abstractThe need to survive in extreme environments has furnished haloarchaea with a series of components specially adapted to work in such conditions. The possible application of these molecules in the pharmaceutical and industrial fields has received increasing attention; however, many potential bioactivities of haloarchaea are still poorly explored. In this paper, we describe the isolation and identification of two new haloarchaeal strains from the saltern ponds located in the marshlands of the Odiel River, in the southwest of Spain, as well as the in vitro assessment of their antioxidant, antimicrobial, and bioactive properties. The acetone extract obtained from the new isolated Haloarcula strain exhibited the highest antioxidant activity, while the acetone extracts from both isolated strains demonstrated a strong antimicrobial activity, especially against other halophilic microorganisms. Moreover, these extracts showed a remarkable ability to inhibit the enzyme cyclooxygenase-2 and to activate the melanogenic enzyme tyrosinase, indicating their potential against chronic inflammation and skin pigmentation disorders. Finally, the aqueous protein-rich extracts obtained from both haloarchaea exhibited an important inhibitory effect on the activity of the acetylcholinesterase enzyme, involved in the hydrolysis of cholinergic neurotransmitters and related to several neurological diseases.pt_PT
dc.description.sponsorshipUniversity of Huelva: EPIT 2016-17 INTERREG VA POCTEP: 055 ALGARED_PLUS_5E SUBV. COOP.ALENTEJO-ALGARVE-ANDALUCIA 2019pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/biology9090298pt_PT
dc.identifier.issn2079-7737
dc.identifier.urihttp://hdl.handle.net/10400.1/14818
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnti-inflammatorypt_PT
dc.subjectHaloarchaea Biology 2020pt_PT
dc.subjectAntioxidantpt_PT
dc.subjectAntimicrobialpt_PT
dc.subjectBioactive substancespt_PT
dc.titleAntioxidant, antimicrobial, and bioactive potential of two new haloarchaeal strains isolated from Odiel Salterns (Southwest Spain)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue9pt_PT
oaire.citation.startPage298pt_PT
oaire.citation.titleBiologypt_PT
oaire.citation.volume9pt_PT
person.familyNameVarela
person.familyNameBarreira
person.givenNameJoão
person.givenNameLuísa
person.identifier.ciencia-id6D1A-17E5-1400
person.identifier.orcid0000-0003-3101-693X
person.identifier.orcid0000-0002-4077-855X
person.identifier.ridM-4223-2013
person.identifier.scopus-author-id55741416000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd339a9e7-bc32-49c4-ba48-a17343d40092
relation.isAuthorOfPublicationce3d77be-25df-4257-b5b3-aca8cff24116
relation.isAuthorOfPublication.latestForDiscoveryd339a9e7-bc32-49c4-ba48-a17343d40092

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
biology-09-00298-v2.pdf
Size:
2.17 MB
Format:
Adobe Portable Document Format
Download

Collections

CCM2-Artigos (em revistas ou actas indexadas)