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Transcriptomic effects of the non-steroidal anti-inflammatory drug Ibuprofen in the marine bivalve Mytilus galloprovincialis Lam

2016-08Journal article Open Access
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dc.contributor.authorMaria, Vera L.
dc.contributor.authorAmorim, Monica J. B.
dc.contributor.authorBebianno, Maria João
dc.contributor.authorDondero, Francesco
dc.date.accessioned2017-04-07T15:56:18Z
dc.date.available2017-04-07T15:56:18Z
dc.date.issued2016-08
dc.description.abstractThe transcriptomic effects of Ibuprofen (IBU) in the digestive gland tissue of Mytilus galloprovincialis Lam. specimens exposed at low environmental concentrations (250 ng L-1) are presented. Using a 1.7 K feature cDNA microarray along with linear models and empirical Bayes statistical methods 225 differentially expressed genes were identified in mussels treated with IBU across a 15-day period. Transcriptional dynamics were typical of an adaptive response with a peak of gene expression change at day 7 (177 features, representing about 11% of sequences available for analysis) and an almost full recovery at the end of the exposure period. Functional genomics by means of Gene Ontology term analysis unraveled typical mussel stress responses i.e. aminoglycan (chitin) metabolic processes but also more specific effects such as the regulation of NF-kappa B transcription factor activity. (C) 2016 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.marenvres.2016.05.010
dc.identifier.issn0141-1136
dc.identifier.otherAUT: MBE00379;
dc.identifier.urihttp://hdl.handle.net/10400.1/9372
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.isbasedonWOS:000381168000004
dc.titleTranscriptomic effects of the non-steroidal anti-inflammatory drug Ibuprofen in the marine bivalve Mytilus galloprovincialis Lam
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F26970%2F2006/PT
oaire.citation.endPage39
oaire.citation.startPage31
oaire.citation.titleMarine Environmental Research
oaire.citation.volume119
oaire.fundingStreamSFRH
person.familyNameMaria
person.familyNameBebianno
person.givenNameVera Lúcia
person.givenNameMaria
person.identifier.ciencia-id7C1D-5627-D3BC
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0002-0331-3489
person.identifier.orcid0000-0003-1492-8566
person.identifier.ridI-5142-2013
person.identifier.scopus-author-id7004664869
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication18c7065a-4bd7-42b2-ba58-ae4c064554b9
relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery18c7065a-4bd7-42b2-ba58-ae4c064554b9
relation.isProjectOfPublicationcdca53b2-fda9-479b-a618-14fc6686b96d
relation.isProjectOfPublication.latestForDiscoverycdca53b2-fda9-479b-a618-14fc6686b96d

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