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A thyroid hormone regulated asymmetric responsive centre is correlated with eye migration during flatfish metamorphosis

2018-08Journal article Open access
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dc.contributor.authorCampinho, Marco António
dc.contributor.authorSilva, Nádia
dc.contributor.authorMartins, Gabriel G.
dc.contributor.authorAnjos, Liliana
dc.contributor.authorFlorindo, Claudia
dc.contributor.authorRoman-Padilla, Javier
dc.contributor.authorGarcia-Cegarra, Ana
dc.contributor.authorLouro, Bruno
dc.contributor.authorManchado, Manuel
dc.contributor.authorPower, Deborah
dc.date.accessioned2018-12-07T14:52:44Z
dc.date.available2018-12-07T14:52:44Z
dc.date.issued2018-08
dc.description.abstractFlatfish metamorphosis is a unique post-embryonic developmental event in which thyroid hormones (THs) drive the development of symmetric pelagic larva into asymmetric benthic juveniles. One of the eyes migrates to join the other eye on the opposite side of the head. Developmental mechanisms at the basis of the acquisition of flatfish anatomical asymmetry remain an open question. Here we demonstrate that an TH responsive asymmetric centre, determined by deiodinase 2 expression, ventrally juxtaposed to the migrating eye in sole (Solea senegalensis) correlates with asymmetric cranial ossification that in turn drives eye migration. Besides skin pigmentation that is asymmetric between dorsal and ventral sides, only the most anterior head region delimited by the eyes becomes asymmetric whereas the remainder of the head and organs therein stay symmetric. Sub-ocular ossification is common to all flatfish analysed to date, so we propose that this newly discovered mechanism is universal and is associated with eye migration in all flatfish.
dc.identifier.doi10.1038/s41598-018-29957-8
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.1/11187
dc.language.isoeng
dc.peerreviewedyes
dc.publisherNature Publishing Group
dc.relationMOLECULAR AND CELLULAR EFFECTS OF IOXINIL AND DIETHYLSTILBESTROL ON ZEBRAFISH THYROCYTE DEVELOPMENT AND ADULT HOMEOSTASIS
dc.relationTRANSCRIPTOMIC RESPONSES TO THERMAL AND OSMOREGULATORY CHALLENGES OF ANTARCTIC NOTOTHENIOID FISH: AN INSIGHT INTO RESPONSES TO GLOBAL CHANGE AND GENOME EVOLUTION
dc.relationMapping gene networks in asymmetric head development during flatfish metamorphosis.
dc.relationStrategic Project - LA 15 - 2011-2012
dc.relationFunctional biology of thyroid hormones in teleost development
dc.subjectFlounder Paralichthys-Olivaceus
dc.subjectSole Solea-Senegalensis
dc.subjectAtlantic Halibut
dc.subjectLarval
dc.subjectFish
dc.subjectSkin
dc.titleA thyroid hormone regulated asymmetric responsive centre is correlated with eye migration during flatfish metamorphosis
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMOLECULAR AND CELLULAR EFFECTS OF IOXINIL AND DIETHYLSTILBESTROL ON ZEBRAFISH THYROCYTE DEVELOPMENT AND ADULT HOMEOSTASIS
oaire.awardTitleTRANSCRIPTOMIC RESPONSES TO THERMAL AND OSMOREGULATORY CHALLENGES OF ANTARCTIC NOTOTHENIOID FISH: AN INSIGHT INTO RESPONSES TO GLOBAL CHANGE AND GENOME EVOLUTION
oaire.awardTitleMapping gene networks in asymmetric head development during flatfish metamorphosis.
oaire.awardTitleStrategic Project - LA 15 - 2011-2012
oaire.awardTitleFunctional biology of thyroid hormones in teleost development
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F66808%2F2009/PT
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oaire.citation.startPage12267
oaire.citation.titleScientific Reports
oaire.citation.volume8
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person.familyNameCampinho
person.familyNameSilva
person.familyNameAnjos Guerreiro
person.familyNameFlorindo
person.familyNameLouro
person.familyNamePower
person.givenNameMarco António
person.givenNameNádia
person.givenNameLiliana Isabel Tomé
person.givenNameClaudia
person.givenNameBruno
person.givenNameDeborah Mary
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person.identifier.orcid0000-0003-1366-0246
person.identifier.ridD-8833-2013
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