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Antioxidant and anti-inflammatory extracts from sea cucumbers and tunicates induce a pro-osteogenic effect in Zebrafish Larvae

2022-05Journal article Open access
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dc.contributor.authorCarletti, Alessio
dc.contributor.authorCardoso, Carlos
dc.contributor.authorLobo-Arteaga, Jorge
dc.contributor.authorSales, Sabrina
dc.contributor.authorJuliao, Diana
dc.contributor.authorFerreira, Inês
dc.contributor.authorChainho, Paula
dc.contributor.authorDionísio, Maria Ana
dc.contributor.authorGaudêncio, Maria J.
dc.contributor.authorAfonso, Cláudia
dc.contributor.authorLourenço, Helena
dc.contributor.authorCancela, M. Leonor
dc.contributor.authorBandarra, Narcisa M.
dc.contributor.authorJ. Gavaia, Paulo
dc.date.accessioned2022-10-26T14:12:30Z
dc.date.available2022-10-26T14:12:30Z
dc.date.issued2022-05
dc.description.abstractBone metabolic disorders such as osteoporosis are characterized by the loss of mineral from the bone tissue leading to its structural weakening and increased susceptibility to fractures. A growing body of evidence suggests that inflammation and oxidative stress play an important role in the pathophysiological processes involved in the rise of these conditions. As the currently available therapeutic strategies are often characterized by toxic effects associated with their long-term use, natural antioxidants and anti-inflammatory compounds such as polyphenols promise to be a valuable alternative for the prevention and treatment of these disorders. In this scope, the marine environment is becoming an important source of bioactive compounds with potential pharmacological applications. Here, we explored the bioactive potential of three species of holothurians (Echinodermata) and four species of tunicates (Chordata) as sources of antioxidant and anti-inflammatory compounds with a particular focus on polyphenolic substances. Hydroethanolic and aqueous extracts were obtained from animals' biomass and screened for their content of polyphenols and their antioxidant and anti-inflammatory properties. Hydroethanolic fractions of three species of tunicates displayed high polyphenolic content associated with strong antioxidant potential and anti-inflammatory activity. Extracts were thereafter tested for their capacity to promote bone formation and mineralization by applying an assay that uses the developing operculum of zebrafish (Danio rerio) to assess the osteogenic activity of compounds. The same three hydroethanolic fractions from tunicates were characterized by a strong in vivo osteogenic activity, which positively correlated with their anti-inflammatory potential as measured by COX-2 inhibition. This study highlights the therapeutic potential of polyphenol-rich hydroethanolic extracts obtained from three species of tunicates as a substrate for the development of novel drugs for the treatment of bone disorders correlated to oxidative stress and inflammatory processes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fnut.2022.888360pt_PT
dc.identifier.issn2296-861X
dc.identifier.urihttp://hdl.handle.net/10400.1/18434
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Media SApt_PT
dc.relationAquaculture meets Biomedicine: Innovation in Skeletal Health research.
dc.relationAlgarve Centre for Marine Sciences
dc.relationEffects of marine derived extracts on osteogenesis and mineralogenesis
dc.relationMarine and Environmental Sciences Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectOsteoporosispt_PT
dc.subjectNatural bioactivespt_PT
dc.subjectPolyphenolspt_PT
dc.subjectSea cucumberspt_PT
dc.subjectTunicatespt_PT
dc.subjectAnti-inflammatorypt_PT
dc.subjectAntioxidantspt_PT
dc.subjectOsteogenicpt_PT
dc.titleAntioxidant and anti-inflammatory extracts from sea cucumbers and tunicates induce a pro-osteogenic effect in Zebrafish Larvaept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAquaculture meets Biomedicine: Innovation in Skeletal Health research.
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleEffects of marine derived extracts on osteogenesis and mineralogenesis
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/766347/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/2021.05406.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04292%2F2020/PT
oaire.citation.titleFrontiers in Nutritionpt_PT
oaire.citation.volume9pt_PT
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCarletti
person.familyNameCancela
person.familyNameGavaia
person.givenNameAlessio
person.givenNameM. Leonor
person.givenNamePaulo
person.identifier.ciencia-idBE18-E938-C489
person.identifier.ciencia-idB619-FC16-D007
person.identifier.orcid0000-0003-2593-2499
person.identifier.orcid0000-0003-3114-6662
person.identifier.orcid0000-0002-9582-1957
person.identifier.ridA-6470-2011
person.identifier.scopus-author-id6507104377
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isProjectOfPublication29e15538-1493-4e61-8be8-055155b79344
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