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Deeper Insights on Alchornea cordifolia (Schumach. & Thonn.) Müll.Arg extracts: chemical profiles, biological abilities, network analysis and molecular docking

2021-02-04Journal article Open access
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dc.contributor.authorSinan, Kouadio Ibrahime
dc.contributor.authorAk, Gunes
dc.contributor.authorEtienne, Ouattara Katinan
dc.contributor.authorJekő, József
dc.contributor.authorCziáky, Zoltán
dc.contributor.authorGupcsó, Katalin
dc.contributor.authorRodrigues, Maria Joao
dc.contributor.authorCustódio, Luísa
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorSharmeen, Jugreet B.
dc.contributor.authorBrunetti, Luigi
dc.contributor.authorLeone, Sheila
dc.contributor.authorRecinella, Lucia
dc.contributor.authorChiavaroli, Annalisa
dc.contributor.authorOrlando, Giustino
dc.contributor.authorMenghini, Luigi
dc.contributor.authorTacchini, Massimo
dc.contributor.authorFerrante, Claudio
dc.contributor.authorZengin, Gokhan
dc.date.accessioned2021-03-08T21:51:40Z
dc.date.available2021-03-08T21:51:40Z
dc.date.issued2021-02-04
dc.date.updated2021-02-26T14:40:04Z
dc.description.abstract<i>Alchornea cordifolia</i> (Schumach. & Thonn.) Müll. Arg. is a well-known African medicinal plant traditionally used for various healing purposes. In the present study, methanolic, ethyl acetate and infusion extracts of <i>A. cordifolia</i> leaves were studied for their total phenolic and flavonoid contents and screened for their chemical composition. Moreover, the enzyme (acetyl- and butyryl-cholinesterases, α-amylase, α-glucosidase, and tyrosinase) inhibitory and cytotoxicity activities on HepG2: human hepatocellular carcinoma cells, B16 4A5: murine melanoma cells, and S17: murine bone marrow (normal) cells of extracts were evaluated. Finally, components-targets and docking analyzes were conducted with the aim to unravel the putative mechanisms underlying the observed bio-pharmacological effects. Interestingly, the infusion and methanolic extracts showed significantly higher total phenolic and flavonoid contents compared with the ethyl acetate extract (TPC: 120.38–213.12 mg GAE/g and TFC: 9.66–57.18 mg RE/g). Besides, the methanolic extracts followed by the infusion extracts were revealed to contain a higher number of compounds (84 and 74 compounds, respectively), while only 64 compounds were observed for the ethyl acetate extract. Gallic acid, ellagic acid, shikimic acid, rutin, quercetin, myricetin, vitexin, quercitrin, kaempferol, and naringenin were among the compounds that were commonly identified in all the studied extracts. Additionally, the methanolic and infusion extracts displayed higher antioxidant capacity than ethyl acetate extract in all assays performed. In ABTS and DPPH radical scavenging assays, the methanol extract (500.38 mg TE/g for DPPH and 900.64 mg TE/g for ABTS) exhibited the best ability, followed by the water and ethyl acetate extracts. Furthermore, the extracts exhibited differential enzyme inhibitory profiles. In particular, the methanolic and infusion extracts showed better cytotoxic selectivity activity against human hepatocellular carcinoma cells. Overall, this study demonstrated <i>A cordifolia</i> to be a species worthy of further investigations, given its richness in bioactive phytochemicals and wide potentialities for antioxidants and pharmacological agents.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifierdoi: 10.3390/biom11020219
dc.identifier.citationBiomolecules 11 (2): 219 (2021)pt_PT
dc.identifier.doi10.3390/biom11020219pt_PT
dc.identifier.issn2218-273X
dc.identifier.urihttp://hdl.handle.net/10400.1/15191
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAlchornea cordifoliapt_PT
dc.subjectAntioxidantpt_PT
dc.subjectEnzyme inhibitionpt_PT
dc.subjectChemical profilept_PT
dc.subjectCytotoxicitypt_PT
dc.subjectBioinformaticspt_PT
dc.titleDeeper Insights on Alchornea cordifolia (Schumach. & Thonn.) Müll.Arg extracts: chemical profiles, biological abilities, network analysis and molecular dockingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.startPage219pt_PT
oaire.citation.titleBiomoleculespt_PT
oaire.citation.volume11pt_PT
person.familyNameRodrigues
person.familyNameCustódio
person.givenNameMaria João
person.givenNameLuísa
person.identifierR-004-VNG
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication12c32925-de9e-4289-bdd5-1d655d7a278c
relation.isAuthorOfPublicationf9cfed0f-6b67-413e-988c-ac7397183471
relation.isAuthorOfPublication.latestForDiscoveryf9cfed0f-6b67-413e-988c-ac7397183471

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