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Vertebrate SLRP family evolution and the subfunctionalization of osteoglycin gene duplicates in teleost fish

2018-12-13Journal article Open access
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dc.contributor.authorCosta, Rita
dc.contributor.authorBrazona, Rute Sofia Tavares Martins
dc.contributor.authorCapilla, E.
dc.contributor.authorAnjos, Liliana
dc.contributor.authorPower, Deborah
dc.date.accessioned2019-01-04T13:17:46Z
dc.date.available2019-01-04T13:17:46Z
dc.date.issued2018-12-13
dc.date.updated2019-01-01T07:33:14Z
dc.description.abstractBackground Osteoglycin (OGN, a.k.a. mimecan) belongs to cluster III of the small leucine-rich proteoglycans (SLRP) of the extracellular matrix (ECM). In vertebrates OGN is a characteristic ECM protein of bone. In the present study we explore the evolution of SLRP III and OGN in teleosts that have a skeleton adapted to an aquatic environment. Results The SLRP gene family has been conserved since the separation of chondrichthyes and osteichthyes. Few gene duplicates of the SLRP III family exist even in the teleosts that experienced a specific whole genome duplication. One exception is ogn for which duplicate copies were identified in fish genomes. The ogn promoter sequence and in vitro mesenchymal stem cell (MSC) cultures suggest the duplicate ogn genes acquired divergent functions. In gilthead sea bream (Sparus aurata) ogn1 was up-regulated during osteoblast and myocyte differentiation in vitro, while ogn2 was severely down-regulated during bone-derived MSCs differentiation into adipocytes in vitro. Conclusions Overall, the phylogenetic analysis indicates that the SLRP III family in vertebrates has been under conservative evolutionary pressure. The retention of the ogn gene duplicates in teleosts was linked with the acquisition of different functions. The acquisition by OGN of functions other than that of a bone ECM protein occurred early in the vertebrate lineage.pt_PT
dc.description.sponsorshipNational funds through FCT – Foundation for Science and Technology (UID/ Multi/04326/2016).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMC Evolutionary Biology. 2018 Dec 13;18(1):191pt_PT
dc.identifier.doi10.1186/s12862-018-1310-2pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.1/12284
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.relationBuilding a biological knowledge-base on fish lifecycles for competitive, sustainable European aquaculture
dc.rights.holderThe Author(s).
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSmall leucine-rich proteoglycan (SLRP) familypt_PT
dc.subjectOsteoglycinpt_PT
dc.subjectMyocytespt_PT
dc.subjectOsteoblastspt_PT
dc.subjectAdipocytespt_PT
dc.subjectTeleostspt_PT
dc.titleVertebrate SLRP family evolution and the subfunctionalization of osteoglycin gene duplicates in teleost fishpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBuilding a biological knowledge-base on fish lifecycles for competitive, sustainable European aquaculture
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/222719/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F81625%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F66742%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F79105%2F2011/PT
oaire.citation.issue1pt_PT
oaire.citation.startPage191pt_PT
oaire.citation.titleBMC Evolutionary Biologypt_PT
oaire.citation.volume18pt_PT
oaire.fundingStreamFP7
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
person.familyNameCosta
person.familyNameMartins
person.familyNameAnjos Guerreiro
person.familyNamePower
person.givenNameRita
person.givenNameRute Sofia Tavares
person.givenNameLiliana Isabel Tomé
person.givenNameDeborah Mary
person.identifierAAK-3800-2020
person.identifier.ciencia-id8219-DFF3-929F
person.identifier.ciencia-idA418-0899-1BD9
person.identifier.ciencia-id6D18-2D1C-A45C
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-6975-7576
person.identifier.orcid0000-0001-5804-2981
person.identifier.orcid0000-0001-9474-522X
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridO-9136-2018
person.identifier.scopus-author-id57097731700
person.identifier.scopus-author-id8575757700
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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