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Metallothionein levels in Algerian mice (Mus spretus) exposed to elemental pollution: an ecophysiological approach

2008Journal article Restricted access
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dc.contributor.authorMarques, Carla Cristina
dc.contributor.authorGabriel, Sofia Isabel
dc.contributor.authorPinheiro, Teresa
dc.contributor.authorViegas-Crespo, Ana Maria
dc.contributor.authorMathias, Maria da Luz
dc.contributor.authorBebianno, Maria João
dc.date.accessioned2020-05-05T09:11:51Z
dc.date.available2020-05-05T09:11:51Z
dc.date.issued2008
dc.description.abstractThe potential use of metallothioneins (MTs) as biomarkers of trace metal contamination was evaluated for the first time in the Algerian mouse (Mus spretus). Mice were collected seasonally in an abandoned mining area (Aljustrel) and in a reference area, both located in southern Portugal. MT levels were quantified in liver and kidney by differential pulse polarography and hepatic elemental concentrations (Mn, Fe, Cu, Zn, Se) were determined by particle-induced X-ray emission. Hepatic iron and selenium concentrations were elevated in mice from Aljustrel mine when compared to reference animals. MTs levels were averagely higher in mice from Aljustrel than those originated from the reference area. A season-dependent significant effect was found on the hepatic and renal MT concentrations, characterized by higher levels in winter and lower in autumn. In contaminated mice positive relationship between liver elemental contents (Cu in autumn and Fe in winter) and MTs were found. The seasonal variation of MT suggests that probably physiological and environmental factors could influence hepatic and renal MT induction. Results seem to imply that some environmental disturbance occur in the vicinity of the Aljustrel mine. Therefore, for the management purposes MT levels should be followed in liver of M. spretus, especially in winter. Furthermore, other physiological factors that could influence MT expression and turnover in Algerian mouse should also be monitored.pt_PT
dc.description.sponsorshipPOCTI/39917/BSE/2001, FCT/SFRH/BD/5018/2001pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.chemosphere.2007.11.024pt_PT
dc.identifier.issn0045-6535
dc.identifier.urihttp://hdl.handle.net/10400.1/13833
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAnimalspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectBody weightpt_PT
dc.subjectEnvironmental monitoringpt_PT
dc.subjectKidneypt_PT
dc.subjectLiverpt_PT
dc.subjectMetallothioneinpt_PT
dc.subjectMetalspt_PT
dc.subjectMiningpt_PT
dc.subjectOrgan sizept_PT
dc.subjectPortugalpt_PT
dc.subjectSeasonspt_PT
dc.subjectSoil pollutantspt_PT
dc.subjectEcosystempt_PT
dc.subjectMicept_PT
dc.subjectHeavypt_PT
dc.titleMetallothionein levels in Algerian mice (Mus spretus) exposed to elemental pollution: an ecophysiological approachpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1347pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage1340pt_PT
oaire.citation.titleChemospherept_PT
oaire.citation.volume71pt_PT
person.familyNameBebianno
person.givenNameMaria
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32

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