Publication
Tribbles gene expression profiles in colorectal cancer
| dc.contributor.author | Fernandes, Mónica T. | |
| dc.contributor.author | Yassuda, Victor | |
| dc.contributor.author | Bragança, José | |
| dc.contributor.author | Link, Wolfgang | |
| dc.contributor.author | Ferreira, Bibiana | |
| dc.contributor.author | De Sousa-Coelho, Ana Luísa | |
| dc.date.accessioned | 2022-01-04T15:55:08Z | |
| dc.date.available | 2022-01-04T15:55:08Z | |
| dc.date.issued | 2021-11-09 | |
| dc.date.updated | 2021-12-23T15:06:22Z | |
| dc.description.abstract | Colorectal cancer (CRC) is the third most common cancer and the second leading cause of death due to cancer in the world. Therefore, the identification of novel druggable targets is urgently needed. Tribbles proteins belong to a pseudokinase family, previously recognized in CRC as oncogenes and potential therapeutic targets. Here, we analyzed the expression of <i>TRIB1</i>, <i>TRIB2</i>, and <i>TRIB3</i> simultaneously in 33 data sets from CRC based on available GEO profiles. We show that all three Tribbles genes are overrepresented in CRC cell lines and primary tumors, though depending on specific features of the CRC samples. Higher expression of TRIB2 in the tumor microenvironment and TRIB3 overexpression in an early stage of CRC development, unveil a potential and unexplored role for these proteins in the context of CRC. Differential Tribbles expression was also explored in diverse cellular experimental conditions where either genetic or pharmacological approaches were used, providing novel hints for future research. This comprehensive bioinformatic analysis provides new insights into Tribbles gene expression and transcript regulation in CRC. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Gastrointestinal Disorders 3 (4): 218-236 (2021) | pt_PT |
| dc.identifier.doi | 10.3390/gidisord3040021 | pt_PT |
| dc.identifier.issn | 2624-5647 | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/17429 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | MDPI | pt_PT |
| dc.relation | Characterizing the clinical relevance and the mechanism underlying TRIB2-mediated drug resistance to MEK inhibitiors in the context of melanoma | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Tribbles | pt_PT |
| dc.subject | Colorectal cancer | pt_PT |
| dc.subject | Oncogenes | pt_PT |
| dc.subject | Gene expression | pt_PT |
| dc.subject | Transcriptional regulation | pt_PT |
| dc.title | Tribbles gene expression profiles in colorectal cancer | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Characterizing the clinical relevance and the mechanism underlying TRIB2-mediated drug resistance to MEK inhibitiors in the context of melanoma | |
| oaire.awardURI | info:eu-repo/grantAgreement/EC/H2020/748585/EU | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-ONC%2F4167%2F2020/PT | |
| oaire.citation.endPage | 236 | pt_PT |
| oaire.citation.issue | 4 | pt_PT |
| oaire.citation.startPage | 218 | pt_PT |
| oaire.citation.title | Gastrointestinal Disorders | pt_PT |
| oaire.citation.volume | 3 | pt_PT |
| oaire.fundingStream | H2020 | |
| oaire.fundingStream | 3599-PPCDT | |
| person.familyName | Teotónio Fernandes | |
| person.familyName | Bragança | |
| person.familyName | ferreira | |
| person.familyName | De Sousa-Coelho | |
| person.givenName | Mónica Alexandra | |
| person.givenName | José | |
| person.givenName | Bibiana | |
| person.givenName | Ana Luísa | |
| person.identifier.ciencia-id | D21D-88F0-DBD1 | |
| person.identifier.ciencia-id | AC1D-FA9D-F66F | |
| person.identifier.ciencia-id | A311-E925-09C5 | |
| person.identifier.ciencia-id | 691B-A574-28ED | |
| person.identifier.orcid | 0000-0002-1206-1367 | |
| person.identifier.orcid | 0000-0001-9566-400X | |
| person.identifier.orcid | 0000-0003-4772-9395 | |
| person.identifier.orcid | 0000-0002-8451-4302 | |
| person.identifier.scopus-author-id | 6602220001 | |
| project.funder.identifier | http://doi.org/10.13039/501100008530 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | European Commission | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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