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In vitro susceptibility of Leishmania infantum to Artemisinin derivatives and selected trioxolanes

2015-08Journal article Restricted access
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dc.contributor.authorCortes, Sofia
dc.contributor.authorAlbuquerque, Andreia
dc.contributor.authorCabral, Lília
dc.contributor.authorLopes, Liliana
dc.contributor.authorCampino, Lenea
dc.contributor.authorCristiano, Maria L. S.
dc.date.accessioned2018-12-07T14:52:39Z
dc.date.available2018-12-07T14:52:39Z
dc.date.issued2015-08
dc.description.abstractLeishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and intramacrophage amastigote forms of Leishmania infantum. The trioxolanes LC50 and LC95 presented the best activity and safety profiles, showing potential for further studies in the context of leishmanial therapy. Our results indicate that the compounds tested exhibit peroxide-dependent activity.
dc.description.sponsorshipFCT (Portuguese Science and Technology Foundation); FEDER [PTDC/CVT/112371/2009, PEst-C/MAR/LA0015/2013, PEst-C/MAR/LA0015/2014, SERH/BPD/44450/2008]; CCMAR/CIMAR
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1128/AAC.00298-15
dc.identifier.issn0066-4804
dc.identifier.issn1098-6596
dc.identifier.urihttp://hdl.handle.net/10400.1/11151
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAmerican Society for Microbiology
dc.relationNew Leishmania species and hybrids- risk of introduction and implications to the pathogeny of infection
dc.subjectSynthetic Trioxolane
dc.subjectAntimalarial
dc.subjectDispiro-1,2,4-Trioxolanes
dc.subjectChemotherapy
dc.subjectPeroxides
dc.titleIn vitro susceptibility of Leishmania infantum to Artemisinin derivatives and selected trioxolanes
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNew Leishmania species and hybrids- risk of introduction and implications to the pathogeny of infection
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCVT%2F112371%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FMAR%2FLA0015%2F2013/PT
oaire.citation.endPage5035
oaire.citation.issue8
oaire.citation.startPage5032
oaire.citation.titleAntimicrobial Agents and Chemotherapy
oaire.citation.volume59
oaire.fundingStream3599-PPCDT
oaire.fundingStreamCOMPETE
person.familyNameCabral
person.familyNameCristiano
person.givenNameLília
person.givenNameMaria de Lurdes
person.identifier.ciencia-id3510-24A8-36B6
person.identifier.ciencia-idE411-6006-5A01
person.identifier.orcid0000-0001-9362-8128
person.identifier.orcid0000-0002-9447-2855
person.identifier.ridM-4279-2013
person.identifier.ridG-2345-2012
person.identifier.scopus-author-id9238724800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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relation.isAuthorOfPublicationb16751a6-748e-44b0-9c59-058cbd5b2cc3
relation.isAuthorOfPublication.latestForDiscoveryb16751a6-748e-44b0-9c59-058cbd5b2cc3
relation.isProjectOfPublicationa99e3bd1-a633-4b25-ac98-34060fb926e1
relation.isProjectOfPublication54af5688-34c3-4241-8c3e-ae96076831ff
relation.isProjectOfPublication.latestForDiscoverya99e3bd1-a633-4b25-ac98-34060fb926e1

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