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Identification of Predominant Phytochemical Compounds and Cytotoxic Activity of Wild Olive Leaves (Olea europaea L. ssp sylvestris) Harvested in South Portugal

dc.contributor.authorMakowska-Was, Justyna
dc.contributor.authorGalanty, Agnieszka
dc.contributor.authorGdula-Argasinska, Joanna
dc.contributor.authorTyszka-Czochara, Malgorzata
dc.contributor.authorSzewczyk, Agnieszka
dc.contributor.authorNunes, Ricardo
dc.contributor.authorCarvalho, Isabel S.
dc.contributor.authorMichalik, Marta
dc.contributor.authorPasko, Pawel
dc.date.accessioned2019-11-20T15:07:46Z
dc.date.available2019-11-20T15:07:46Z
dc.date.issued2017-03
dc.description.abstractThis study has been aimed at providing a qualitative and quantitative evaluation of selected phytochemicals such as phenolic acids, flavonoids, oleuropein, fatty acids profile, and volatile oil compounds, present in wild olive leaves harvested in Portugal, as well as at determining their antioxidant and cytotoxic potential against human melanoma HTB-140 and WM793, prostate cancer DU-145 and PC-3, hepatocellular carcinoma Hep G2 cell lines, as well as normal human skin fibroblasts BJ and prostate epithelial cells PNT2. Gallic, protocatechuic, p-hydroxybenzoic, vanillic acids, apigenin 7-O-glucoside, luteolin 7-O-glucoside, and rutin were identified in olive leaves. The amount of oleuropein was equal to 22.64 g/kg dry weight. (E)-Anethole (32.35%), fenchone (11.89%), and (Z)-3-nonen-1-ol (8%) were found to be the main constituents of the oil volatile fraction, whereas palmitic, oleic, and alpha-linolenic acid were determined to be dominating fatty acids. Olive leaves methanol extract was observed to exerted a significant, selective cytotoxic effect on DU-145 and PC-3 cell lines. Except the essential oil composition, evaluated wild olive leaves, with regard to their quantitative and qualitative composition, do not substantially differ from the leaves of other cultivars grown for industrial purposes and they reveal considerable antioxidant and cytotoxic properties. Thus, the wild species may prove to be suitable for use in traditional medicine as cancer chemoprevention.
dc.description.sponsorshipPolish Ministry of Science and Higher Education [K/ZDS/004122, K/ZDS/006239, K/ZDS/006228]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1002/cbdv.201600331
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.urihttp://hdl.handle.net/10400.1/13202
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPerformance liquid-chromatography
dc.subject2 Different seasons
dc.subjectPhenolic-compounds
dc.subjectAntioxidant activity
dc.subjectBiological-activities
dc.subjectVolatile fractions
dc.subjectTunisian cultivars
dc.subjectLeaf extracts
dc.subjectFruits
dc.subjectOleuropein
dc.titleIdentification of Predominant Phytochemical Compounds and Cytotoxic Activity of Wild Olive Leaves (Olea europaea L. ssp sylvestris) Harvested in South Portugal
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3
oaire.citation.startPagee1600331
oaire.citation.titleChemistry & Biodiversity
oaire.citation.volume14
person.familyNameNunes
person.familyNameSaraiva de Carvalho
person.givenNameRicardo
person.givenNameIsabel Maria Marques
person.identifier.ciencia-id591A-3777-B036
person.identifier.orcid0000-0002-0500-6300
person.identifier.orcid0000-0001-8057-3404
person.identifier.scopus-author-id35995183800
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublicationa28aa189-2764-4b32-9698-b0f242e415ab
relation.isAuthorOfPublicationaf26e659-578b-4e5f-a649-384cd5e4f8e3
relation.isAuthorOfPublication.latestForDiscoverya28aa189-2764-4b32-9698-b0f242e415ab

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