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Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata

2012-02Journal article Restricted access
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dc.contributor.authorRafael, Marta S.
dc.contributor.authorLaizé, Vincent
dc.contributor.authorBensimon-Brito, A.
dc.contributor.authorLeite, Ricardo
dc.contributor.authorSchüle, R.
dc.contributor.authorCancela, Leonor
dc.date.accessioned2014-06-12T11:32:03Z
dc.date.available2014-06-12T11:32:03Z
dc.date.issued2012-02
dc.date.updated2014-06-03T09:39:47Z
dc.description.abstractFour-and-a-half LIM domains protein 2 (FHL2) is involved in major cellular mechanisms such as regulation of gene transcription and cytoskeleton modulation, participating in physiological control of cardiogenesis and osteogenesis. Knowledge on underlying mechanisms is, however, limited. We present here new data on FHL2 protein and its role during vertebrate development using a marine teleost fish, the gilthead seabream (Sparus aurata L.). In silico comparison of vertebrate protein sequences and prediction of LIM domain three-dimensional structure revealed a high degree of conservation, suggesting a conserved function throughout evolution. Determination of sites and levels of FHL2 gene expression in seabream indicated a central role for FHL2 in the development of heart and craniofacial musculature, and a potential role in tissue calcification. Our data confirmed the key role of FHL2 protein during vertebrate development and gave new insights into its particular involvement in craniofacial muscle development and specificity for slow fibers.por
dc.identifier.citationRafael, M.S.; Laizé, V.; Bensimon-Brito, A.; Leite, R.B.; Schüle, R.; Cancela, M.L.Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata, Cellular and Molecular Life Sciences, 69, 3, 423-434, 2012.por
dc.identifier.doihttp://dx.doi.org/10.1007/s00018-011-0754-y
dc.identifier.issn1420-682X
dc.identifier.otherAUT: LCA00739
dc.identifier.urihttp://hdl.handle.net/10400.1/4279
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://download.springer.com/static/pdf/826/art%253A10.1007%252Fs00018-011-0754-y.pdf?auth66=1402745314_9bb2824b2aac11da6b6fd00ebae8462c&ext=.pdfpor
dc.subject3D protein structurepor
dc.subjectMuscle developmentpor
dc.subjectGene expression patternspor
dc.subjectTeleost fishpor
dc.subjectFour-and-a-half LIM domains protein 2, FHL2por
dc.titleFour-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus auratapor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage434por
oaire.citation.issue3por
oaire.citation.startPage423por
oaire.citation.titleCellular and Molecular Life Sciencespor
oaire.citation.volume69por
person.familyNameRafael
person.familyNameLaizé
person.familyNameBensimon-Brito
person.familyNameLeite
person.familyNameCancela
person.givenNameMarta
person.givenNameVincent
person.givenNameAnabela
person.givenNameRicardo
person.givenNameM. Leonor
person.identifier1460592
person.identifier447622
person.identifier.ciencia-id1C10-BF17-0DD7
person.identifier.ciencia-id8419-63A7-D0E5
person.identifier.ciencia-idF115-256E-C84D
person.identifier.orcid0000-0002-5518-9790
person.identifier.orcid0000-0001-9565-9198
person.identifier.orcid0000-0003-1663-2232
person.identifier.orcid0000-0002-9622-3895
person.identifier.orcid0000-0003-3114-6662
person.identifier.ridB-4463-2008
person.identifier.ridN-7291-2014
person.identifier.ridB-3389-2008
person.identifier.scopus-author-id15078212800
person.identifier.scopus-author-id6602982778
person.identifier.scopus-author-id36154529200
person.identifier.scopus-author-id8362650900
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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