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Global phylogeography and evolution of chelonid fibropapilloma-associated herpesvirus

2012-05Journal article Open access
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dc.contributor.authorPatricio, A. R.
dc.contributor.authorHerbst, L. H.
dc.contributor.authorDuarte, A.
dc.contributor.authorVelez-Zuazo, X.
dc.contributor.authorLoureiro, Nuno de Santos
dc.contributor.authorPereira, N.
dc.contributor.authorTavares, L.
dc.contributor.authorToranzos, G. A.
dc.date.accessioned2018-12-07T14:53:50Z
dc.date.available2018-12-07T14:53:50Z
dc.date.issued2012-05
dc.description.abstractA global phylogeny for chelonid fibropapilloma-associated herpesvirus (CFPHV), the most likely aetiological agent of fibropapillomatosis (FP) in sea turtles, was inferred, using dated sequences, through Bayesian Markov chain Monte Carlo analysis and used to estimate the virus evolutionary rate independent of the evolution of the host, and to resolve the phylogenetic positions of new haplotypes from Puerto Rico and the Gulf of Guinea. Four phylogeographical groups were identified: eastern Pacific, western Atlantic/eastern Caribbean, mid-west Pacific and Atlantic. The latter comprises the Gulf of Guinea and Puerto Rico, suggesting recent virus gene flow between these two regions. One virus haplotype from Florida remained elusive, representing either an independent lineage sharing a common ancestor with all other identified virus variants or an Atlantic representative of the lineage giving rise to the eastern Pacific group. The virus evolutionary rate ranged from 1.62x10(-4) to 2.22x10(-4) substitutions per site per year, which is much faster than what is expected for a herpesvirus. The mean time for the most recent common ancestor of the modern virus variants was estimated at 192.90-429.71 years ago, which, although more recent than previous estimates, still supports an interpretation that the global FP pandemic is not the result of a recent acquisition of a virulence mutation(s). The phylogeographical pattern obtained seems partially to reflect sea turtle movements, whereas altered environments appear to be implicated in current FP outbreaks and in the modern evolutionary history of CFPHV.
dc.description.sponsorshipDNER-PR; US NMFS (NMFS-NOAA) [NA08NMF4720436]; US-Fish and Wildlife Service (USFWS); Sociedad Chelonia; WIDECAST; US Environmental Protection Agency (US-EPA); Lisbon Oceanarium, Portugal; Interdisciplinary Research Center for Animal Health of the Faculty of Veterinary Medicine of the Technical University of Lisbon (FMV/TUL)
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1099/vir.0.038950-0
dc.identifier.issn0022-1317
dc.identifier.urihttp://hdl.handle.net/10400.1/11713
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSoc General Microbiology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGreen Turtle Fibropapillomatosis
dc.subjectSimplex-virus type-1
dc.subjectTime dependency
dc.subjectMarine turtles
dc.subjectSea-turtles
dc.subjectDevelopmental habitats
dc.subjectRecombinant sequences
dc.subjectQuantitative-analysis
dc.subjectMolecular evolution
dc.subjectCaretta-Caretta
dc.titleGlobal phylogeography and evolution of chelonid fibropapilloma-associated herpesvirus
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1045
oaire.citation.startPage1035
oaire.citation.titleJournal of General Virology
oaire.citation.volume93
person.familyNameFigueiredo de Santos Loureiro
person.givenNameNuno Manuel de
person.identifier.ciencia-idD514-3F01-6DE0
person.identifier.orcid0000-0001-7018-7630
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationa281c547-4ec4-4512-ba80-350af27857cf
relation.isAuthorOfPublication.latestForDiscoverya281c547-4ec4-4512-ba80-350af27857cf

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