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Metabolic signatures associated with environmental pollution by metals in DoƱana National Park using P. clarkii as bioindicator

2014Journal article Restricted access
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dc.contributor.authorGago-Tinoco, Amanda
dc.contributor.authorGonzĆ”lez-DomĆ­nguez, RaĆŗl
dc.contributor.authorGarcĆ­a-Barrera, Tamara
dc.contributor.authorBlasco-Moreno, JuliƔn
dc.contributor.authorBebianno, Maria JoĆ£o
dc.contributor.authorGĆ³mez-Ariza, JosĆ©-Luis
dc.date.accessioned2020-04-22T10:28:33Z
dc.date.available2020-04-22T10:28:33Z
dc.date.issued2014
dc.description.abstractBioindicators can reflect the effects of pollutants on their metabolism, being widely used to assess environmental stress. In this sense, the crab Procambarus clarkii has been previously proposed to monitor the contamination in DoƱana National Park (southwest Spain) using conventional biomarkers. In this work, a metabolomic approach based on direct infusion mass spectrometry, which allows an easy and quick study of a large number of metabolites in a single run, was used for pollution assessment of this area, considering the biological response of this organism to contamination. In addition, metal accumulation in crab tissues was determined. Thus, the integrated analysis of metabolomic and metallomic data enabled the study of metabolic response of the organism against pollution. Several metabolites were discovered as potential biomarkers of pollution, such as decreased levels of carnosine, alanine, niacinamide, acetoacetate, pantothenic acid, ascorbate, glucose-6-phosphate, arginine, glucose, lactate, phospholipids, and tryglicerides, as well as elevated levels of acetyl carnitine, phosphocholine, choline, and uric acid. In this way, metal-induced toxicity could be related to metabolic impairments, principally oxidative stress, metabolic dysfunction, and dyslipidemia.pt_PT
dc.description.sponsorshipCTM2012-38720-C03-01, P008-FQM-3554, P009-FQM-4659pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s11356-014-2741-ypt_PT
dc.identifier.issn0944-1344
dc.identifier.urihttp://hdl.handle.net/10400.1/13742
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectDecapodapt_PT
dc.subjectEnvironmental monitoringpt_PT
dc.subjectEnvironmental pollutantspt_PT
dc.subjectEnvironmental pollutionpt_PT
dc.subjectHeavy metal poisoningpt_PT
dc.subjectMalept_PT
dc.subjectMass spectrometrypt_PT
dc.subjectMetalspt_PT
dc.subjectMetalspt_PT
dc.subjectPoisoningpt_PT
dc.subjectSpainpt_PT
dc.subjectMetabolomicspt_PT
dc.subjectHeavypt_PT
dc.titleMetabolic signatures associated with environmental pollution by metals in DoƱana National Park using P. clarkii as bioindicatorpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage13323pt_PT
oaire.citation.issue23pt_PT
oaire.citation.startPage13315pt_PT
oaire.citation.titleEnvironmental Science and Pollution Researchpt_PT
oaire.citation.volume21pt_PT
person.familyNameBebianno
person.givenNameMaria
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32

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