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Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging

2014Journal article Open access
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dc.contributor.authorMouffouk, Fouzi
dc.contributor.authorDornelle, Daniel
dc.contributor.authorLopes, Andre D.
dc.contributor.authorMartins, Jorge
dc.contributor.authorAbu-Salah, Khalid
dc.contributor.authorCosta, Ana M. Rosa da
dc.contributor.authordos Santos, Nuno
dc.contributor.authorSau, Pablo
dc.contributor.authorSimão, Teresa
dc.contributor.authorAlrokayan, Salman A.
dc.date.accessioned2016-01-07T16:52:36Z
dc.date.available2016-01-07T16:52:36Z
dc.date.issued2014
dc.description.abstractEarly cancer detection is a major factor in the reduction of mortality and cancer management cost. Here we developed a smart and targeted micelle-based contrast agent for magnetic resonance imaging (MRI), able to turn on its imaging capability in the presence of acidic cancer tissues. This smart contrast agent consists of pH-sensitive polymeric micelles formed by self-assembly of a diblock copolymer (poly(ethyleneglycol-b-trimethylsilyl methacrylate)), loaded with a gadolinium hydrophobic complex ((t)BuBipyGd) and exploits the acidic pH in cancer tissues. In vitro MRI experiments showed that (t)BuBipyGd-loaded micelles were pH-sensitive, as they turned on their imaging capability only in an acidic microenvironment. The micelle-targeting ability toward cancer cells was enhanced by conjugation with an antibody against the MUC1 protein. The ability of our antibody-decorated micelles to be switched on in acidic microenvironments and to target cancer cells expressing specific antigens, together with its high Gd(III) content and its small size (35-40 nm) reveals their potential use for early cancer detection by MRI.pt_PT
dc.identifier.citationInt. J. Nanomedicine (2015) 10, 63-76pt_PT
dc.identifier.doi10.2147/IJN.S71190pt_PT
dc.identifier.issn1176-9114
dc.identifier.otherAUT: AMC01695; ADL01681;
dc.identifier.urihttp://hdl.handle.net/10400.1/7403
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Society for Nanomedicinept_PT
dc.relationStrategic Project - LA 23 - 2011-2012
dc.relationStrategic Project - UI 4023 - 2011-2012
dc.relation.publisherversionhttp://www.dovepress.com/self-assembled-polymeric-nanoparticles-as-new-smart-contrast-agents-fo-peer-reviewed-article-IJNpt_PT
dc.subjectMicellept_PT
dc.subjectPH-sensitivept_PT
dc.subjectSelf-assemblypt_PT
dc.subjectSmart contrast agentpt_PT
dc.subjectCancer detectionpt_PT
dc.titleSelf-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imagingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - LA 23 - 2011-2012
oaire.awardTitleStrategic Project - UI 4023 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0023%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI4023%2F2011/PT
oaire.citation.endPage76pt_PT
oaire.citation.startPage63pt_PT
oaire.citation.titleInternational Journal of Nanomedicinept_PT
oaire.citation.volume10pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameD. Lopes
person.familyNameRosa da Costa
person.givenNameAndré
person.givenNameAna M
person.identifier2824636
person.identifier305029
person.identifier.ciencia-id351E-856A-0300
person.identifier.ciencia-idA418-A85E-5DB1
person.identifier.orcid0000-0002-9702-1216
person.identifier.orcid0000-0003-0225-9537
person.identifier.ridE-2136-2012
person.identifier.ridE-2165-2012
person.identifier.scopus-author-id7201958625
person.identifier.scopus-author-id53986075100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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