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The genome and transcriptome of Japanese flounder provide insights into flatfish asymmetry

2017-01Journal article Open access
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dc.contributor.authorShao, Changwei
dc.contributor.authorBao, Baolong
dc.contributor.authorXie, Zhiyuan
dc.contributor.authorChen, Xinye
dc.contributor.authorLi, Bo
dc.contributor.authorJia, Xiaodong
dc.contributor.authorYao, Qiulin
dc.contributor.authorOrti, Guillermo
dc.contributor.authorLi, Wenhui
dc.contributor.authorLi, Xihong
dc.contributor.authorHamre, Kristin
dc.contributor.authorXu, Juan
dc.contributor.authorWang, Lei
dc.contributor.authorChen, Fangyuan
dc.contributor.authorTian, Yongsheng
dc.contributor.authorSchreiber, Alex M.
dc.contributor.authorWang, Na
dc.contributor.authorWei, Fen
dc.contributor.authorZhang, Jilin
dc.contributor.authorDong, Zhongdian
dc.contributor.authorGao, Lei
dc.contributor.authorGai, Junwei
dc.contributor.authorSakamoto, Takashi
dc.contributor.authorMo, Sudong
dc.contributor.authorChen, Wenjun
dc.contributor.authorShi, Qiong
dc.contributor.authorLi, Hui
dc.contributor.authorXiu, Yunji
dc.contributor.authorLi, Yangzhen
dc.contributor.authorXu, Wenteng
dc.contributor.authorShi, Zhiyi
dc.contributor.authorZhang, Guojie
dc.contributor.authorPower, Deborah M.
dc.contributor.authorWang, Qingyin
dc.contributor.authorSchartl, Manfred
dc.contributor.authorChen, Songlin
dc.date.accessioned2018-12-07T14:53:06Z
dc.date.available2018-12-07T14:53:06Z
dc.date.issued2017-01
dc.description.abstractFlatfish have the most extreme asymmetric body morphology of vertebrates. During metamorphosis, one eye migrates to the contralateral side of the skull, and this migration is accompanied by extensive craniofacial transformations and simultaneous development of lopsided body pigmentation(1-5). The evolution of this developmental and physiological innovation remains enigmatic. Comparative genomics of two flatfish and transcriptomic analyses during metamorphosis point to a role for thyroid hormone and retinoic acid signaling, as well as phototransduction pathways. We demonstrate that retinoic acid is critical in establishing asymmetric pigmentation and, via cross-talk with thyroid hormones, in modulating eye migration. The unexpected expression of the visual opsins from the phototransduction pathway in the skin translates illumination differences and generates retinoic acid gradients that underlie the generation of asymmetry. Identifying the genetic underpinning of this unique developmental process answers long-standing questions about the evolutionary origin of asymmetry, but it also provides insight into the mechanisms that control body shape in vertebrates.
dc.description.sponsorshipNational Natural Science Foundation of China [31130057, 31461163005, 31530078, 31472269, 31472262, 31472273]; State 863 High Technology R&D Project of China [2012AA092203, 2012AA10A408, 2012AA10A403-2]; Education and Research of Guangdong Province [2013B090800017]; Taishan Scholar Climb Project Fund of Shandong of China; Taishan Scholar Project Fund of Shandong of China for Young Scientists; Shanghai Universities First-class Disciplines Project of Fisheries; Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning; Shanghai Municipal Science, Special Project on the Integration of Industry
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1038/ng.3732
dc.identifier.issn1061-4036
dc.identifier.issn1546-1718
dc.identifier.urihttp://hdl.handle.net/10400.1/11355
dc.language.isoeng
dc.peerreviewedyes
dc.publisherNature Publishing Group
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHippoglossus L. larvae
dc.subjectThyroid-hormone
dc.subjectRetinoic acid
dc.subjectMetamorphosis
dc.subjectPigmentation
dc.subjectReceptor
dc.subjectEvolution
dc.subjectProduct
dc.subjectGenes
dc.titleThe genome and transcriptome of Japanese flounder provide insights into flatfish asymmetry
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage124
oaire.citation.issue1
oaire.citation.startPage119
oaire.citation.titleNature Genetics
oaire.citation.volume49
person.familyNamePower
person.givenNameDeborah Mary
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0003-1366-0246
person.identifier.scopus-author-id7101806760
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0

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