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The search for an autoimmune origin of psychotic disorders: prevalence of autoantibodies against hippocampus antigens, glutamic acid decarboxylase and nuclear antigens

2021Journal article Open access
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dc.contributor.authorHoffmann, Carolin Correia
dc.contributor.authorZong, Shenghua
dc.contributor.authorMané-Damas, Marina
dc.contributor.authorStevens, Jo
dc.contributor.authorMalyavantham, Kishore
dc.contributor.authorKüçükali, Cem İsmail
dc.contributor.authorTüzün, Erdem
dc.contributor.authorDe Hert, Marc
dc.contributor.authorvan Beveren, Nico J.M.
dc.contributor.authorGonzález-Vioque, Emiliano
dc.contributor.authorArango, Celso
dc.contributor.authorDamoiseaux, Jan G.M.C.
dc.contributor.authorRutten, Bart P.
dc.contributor.authorMolenaar, Peter C.
dc.contributor.authorLosen, Mario
dc.contributor.authorMartinez-Martinez, Pilar
dc.date.accessioned2021-04-20T20:18:53Z
dc.date.available2021-04-20T20:18:53Z
dc.date.issued2021
dc.description.abstractThe etiology of psychotic disorders is still unknown, but in a subgroup of patients symptoms might be caused by an autoimmune reaction. In this study, we tested patterns of autoimmune reactivity against potentially novel hippocampal antigens. Serum of a cohort of 621 individuals with psychotic disorders and 257 controls were first tested for reactivity on neuropil of rat brain sections. Brain reactive sera (67 diseased, 27 healthy) were further tested for antibody binding to glutamic acid decarboxylase (GAD) isotype 65 and 67 by cell-based assay (CBA). A sub-cohort of 199 individuals with psychotic disorders and 152 controls was tested for the prevalence of anti-nuclear antibodies (ANA) on HEp2-substrate as well as for reactivity to double-stranded DNA, ribosomal P (RPP), and cardiolipin (CL). Incubation of rat brain with serum resulted in unidentified hippocampal binding patterns in both diseased and control groups. Upon screening with GAD CBA, one of these patterns was identified as GAD65 in one individual with schizophrenia and also in one healthy individual. Two diseased and two healthy individuals had low antibody levels targeting GAD67 by CBA. Antibody reactivity on HEp-2-substrate was increased in patients with schizoaffective disorder, but only in 3 patients did antibody testing hint at a possible diagnosis of systemic lupus erythematosus. Although reactivity of serum to intracellular antigens might be increased in patients with psychotic disorder, no specific targets could be identified. GAD antibodies are very rare and do not seem increased in serum of patients with psychotic disorders.pt_PT
dc.description.sponsorshipHEALTH-F2-2010-241909pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.schres.2020.12.038pt_PT
dc.identifier.issn0920-9964
dc.identifier.urihttp://hdl.handle.net/10400.1/15428
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPsychosespt_PT
dc.subjectNeuroimmunologypt_PT
dc.subjectAutoantibodiespt_PT
dc.titleThe search for an autoimmune origin of psychotic disorders: prevalence of autoantibodies against hippocampus antigens, glutamic acid decarboxylase and nuclear antigenspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage471pt_PT
oaire.citation.startPage462pt_PT
oaire.citation.titleSchizophrenia Researchpt_PT
oaire.citation.volume228pt_PT
person.familyNameHoffmann
person.givenNameCarolin
person.identifier.ciencia-id211F-792C-1B73
person.identifier.orcid0000-0002-2528-7541
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication50a4d3cc-b575-4d58-8df8-a51bed2914bb
relation.isAuthorOfPublication.latestForDiscovery50a4d3cc-b575-4d58-8df8-a51bed2914bb

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