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Insights into the demographic history of african pygmies from complete mitochondrial genomes

2011-02Journal article Open Access
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dc.contributor.authorBatini, Chiara
dc.contributor.authorLopes, Joao
dc.contributor.authorBehar, Doron M.
dc.contributor.authorCalafell, Francesc
dc.contributor.authorJorde, Lynn B.
dc.contributor.authorvan der Veen, Lolke
dc.contributor.authorQuintana-Murci, Lluis
dc.contributor.authorSpedini, Gabriella
dc.contributor.authorDestro Bisol, Giovanni
dc.contributor.authorComas, David
dc.date.accessioned2018-12-07T14:52:59Z
dc.date.available2018-12-07T14:52:59Z
dc.date.issued2011-02
dc.description.abstractPygmy populations are among the few hunter-gatherers currently living in sub-Saharan Africa and are mainly represented by two groups, Eastern and Western, according to their current geographical distribution. They are scattered across the Central African belt and surrounded by Bantu-speaking farmers, with whom they have complex social and economic interactions. To investigate the demographic history of Pygmy groups, a population approach was applied to the analysis of 205 complete mitochondrial DNA (mtDNA) sequences from ten central African populations. No sharing of maternal lineages was observed between the two Pygmy groups, with haplogroup L1c being characteristic of the Western group but most of Eastern Pygmy lineages falling into subclades of L0a, L2a, and L5. Demographic inferences based on Bayesian coalescent simulations point to an early split among the maternal ancestors of Pygmies and those of Bantu-speaking farmers (similar to 70,000 years ago [ya]). Evidence for population growth in the ancestors of Bantu-speaking farmers has been observed, starting similar to 65,000 ya, well before the diffusion of Bantu languages. Subsequently, the effective population size of the ancestors of Pygmies remained constant over time and similar to 27,000 ya, coincident with the Last Glacial Maximum, Eastern and Western Pygmies diverged, with evidence of subsequent migration only among the Western group and the Bantu-speaking farmers. Western Pygmies show signs of a recent bottleneck 4,000-650 ya, coincident with the diffusion of Bantu Languages, whereas Eastern Pygmies seem to have experienced a more ancient decrease in population size (20,000-4,000 ya). In conclusion, the results of this first attempt at analyzing complete mtDNA sequences at the population level in sub-Saharan Africa not only support previous findings but also offer new insights into the demographic history of Pygmy populations, shedding new light on the ancient peopling of the African continent.
dc.description.sponsorshipDireccion General de Investigacion, Ministerio de Educacion y Ciencia, Spain [CGL2007-61016]; Direccio General de Recerca, Generalitat de Catalunya [2009SGR1101]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1093/molbev/msq294
dc.identifier.issn0737-4038
dc.identifier.urihttp://hdl.handle.net/10400.1/11294
dc.language.isoeng
dc.peerreviewedyes
dc.publisherOxford University Press
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBantu expansion
dc.subjectPopulation-genetics
dc.subjectWestern pygmies
dc.subjectY-chromosome
dc.subjectMtdna
dc.subjectDna
dc.subjectLineages
dc.subjectEastern
dc.subjectEnvironments
dc.subjectHaplogroup
dc.titleInsights into the demographic history of african pygmies from complete mitochondrial genomes
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1110
oaire.citation.issue2
oaire.citation.startPage1099
oaire.citation.titleMolecular Biology and Evolution
oaire.citation.volume28
person.familyNameBatini
person.familyNameLopes
person.familyNameCalafell
person.familyNameQuintana-Murci
person.familyNameDestro Bisol
person.familyNameComas
person.givenNameChiara
person.givenNameJoao
person.givenNameFrancesc
person.givenNameLluis
person.givenNameGiovanni
person.givenNameDavid
person.identifier.ciencia-id591B-6DEB-ECF9
person.identifier.orcid0000-0002-7140-2985
person.identifier.orcid0000-0001-5670-2069
person.identifier.orcid0000-0002-1083-9438
person.identifier.orcid0000-0003-2429-6320
person.identifier.orcid0000-0002-4232-9715
person.identifier.orcid0000-0002-5075-0956
person.identifier.ridC-8595-2014
person.identifier.ridD-5382-2014
person.identifier.scopus-author-id23666331700
person.identifier.scopus-author-id35094054800
person.identifier.scopus-author-id7005098244
person.identifier.scopus-author-id7004396129
person.identifier.scopus-author-id7003976031
rcaap.rightsopenAccess
rcaap.typearticle
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