Repository logo
 
Publication

Mineral metabolism and inflammation: factors related to left ventricular hypertrophy in patients with diabetic nephropathy

2016Journal article Restricted access
Simple item page
dc.contributor.authorJerĂłnimo, Teresa
dc.contributor.authorFragoso, Andr?
dc.contributor.authorMendes, Filipa
dc.contributor.authorSilva, Ana Paula
dc.contributor.authorPimentel, Ana
dc.contributor.authorTavares, Nelson
dc.contributor.authorCamacho, Ana
dc.contributor.authorNeves, Pedro LeĂŁo
dc.date.accessioned2017-04-07T15:56:31Z
dc.date.available2017-04-07T15:56:31Z
dc.date.issued2016
dc.description.abstractLeft ventricular hypertrophy (LVH) is an important risk factor for cardiovascular disease in patients with diabetic nephropathy (DN) and is an independent predictor of mortality in patients with chronic kidney disease (CKD). The aim of this study was to evaluate the association of LVH with mineral metabolism and inflammation in a population of patients with DN. In an observational study were included 119 type 2 diabetic patients with CKD stages 3 and 4. The population was divided into two groups, according to the presence of LVH: group 1 (G-1) with LVH (left ventricular mass index (LVMI) > 125 g/m2 in male patients and LVMI > 110 g/m2 in female patients) and group 2 (G-2) without LVH (LVMI ? 125 g/m2 in male patients and LVMI ? 110 g/m2 in female patients). The patient characteristics of each group were compared regarding several biological and laboratory parameters. Patients with LVH displayed lower values of estimated glomerular filtration rate (eGFR) (p = 0.0001) and albumin (p = 0.046), and higher levels of phosphorus (p = 0.0001), intact parathyroid hormone (iPTH) (p = 0.0001), insulin resistance (HOMA-IR) (p = 0.0001) and interleukin-6 (IL-6) (p = 0.0001), compared with patients without LVH. In a logistic regression model, phosphorus (odd ratio (OR) = 1.825 (1.075-4.414), p = 0.038), iPTH (OR = 1.991 (1.098-3.000), p = 0.004) and IL-6 (OR = 3.538 (1.863-6.719), p = 0.0001) were independently related to LVH. In a multiple linear regression model, phosphorus (r = 0.602, p = 0.038), iPTH (r = 1.009, p = 0.044) and IL-6 (r = 1.264, p = 0.0001) were positively related to LVMI. Phosphorus, PTH and IL-6 were related to LVH in our diabetic population with CKD stages 3 and 4
dc.identifier.issn0872-0169
dc.identifier.urihttp://hdl.handle.net/10400.1/9442
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSociedade Portuguesa de Nefrologia
dc.relation.isbasedonSCIELO:S0872-01692016000200005
dc.titleMineral metabolism and inflammation: factors related to left ventricular hypertrophy in patients with diabetic nephropathy
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage125
oaire.citation.issue2
oaire.citation.startPage121
oaire.citation.titlePortuguese Journal of Nephrology & Hypertension
oaire.citation.volume30
person.familyNameMendes
person.familyNameNeves
person.givenNameFilipa
person.givenNamePedro LeĂŁo
person.identifier.ciencia-id1014-3EA2-C680
person.identifier.orcid0000-0002-0329-8805
person.identifier.orcid0000-0002-8463-0768
person.identifier.scopus-author-id7003907170
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication871b65e7-2325-4468-a518-070543f80346
relation.isAuthorOfPublication788c02e9-1087-4e30-8a34-5379261fc739
relation.isAuthorOfPublication.latestForDiscovery871b65e7-2325-4468-a518-070543f80346

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
9442.pdf
Size:
301.58 KB
Format:
Adobe Portable Document Format
Download

Collections

FCB2-Artigos (em revistas ou actas indexadas)
ULS2-Artigos (em revistas ou actas indexadas)