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Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot

2017-11Journal article Open access
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dc.contributor.authorMilcovich, Gesmi
dc.contributor.authorLettieri, Stefania
dc.contributor.authorAntunes, Filipe E.
dc.contributor.authorMedronho, Bruno
dc.contributor.authorFonseca, Ana C.
dc.contributor.authorCoelho, Jorge F. J.
dc.contributor.authorMarizza, Paolo
dc.contributor.authorPerrone, Francesca
dc.contributor.authorFarra, Rossella
dc.contributor.authorDapas, Barbara
dc.contributor.authorGrassi, Gabriele
dc.contributor.authorGrassi, Mario
dc.contributor.authorGiordani, Silvia
dc.date.accessioned2019-11-20T15:07:13Z
dc.date.available2019-11-20T15:07:13Z
dc.date.issued2017-11
dc.description.abstractOver the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects, specific treatments, higher patient compliance and therefore more effective treatments leading to lower healthcare costs. Within this sector, smart nanotechnology and colloidal self-assembling systems represent pivotal tools able to modulate the delivery of therapeutics. A comprehensive understanding of the processes involved in the self assembly of the colloidal structures discussed therein is essential for the development of relevant biomedical applications. In this review we report the most promising and best performing platforms for specific classes of bioactive molecules and related target, spanning from siRNAs, gene/plasmids, proteins/growth factors, small synthetic therapeutics and bioimaging probes.
dc.description.sponsorshipIstituto Italiano di Tecnologia (IIT)
dc.description.sponsorshipCOST Action [CA 15107]
dc.description.sponsorshipPeople Program (Marie Curie Actions) of the European Union's Seventh Framework Program under REA [606713 BIBAFOODS]
dc.description.sponsorshipPortuguese Foundation for Science and Technology (FCT) [PTDC/AGR-TEC/4814/2014, IF/01005/2014]
dc.description.sponsorshipFundacao para a Ciencia e Tecnologia [SFRH/BPD/99982/2014]
dc.description.sponsorshipDanish National Research Foundation [DNRF 122]
dc.description.sponsorshipVillum Foundation [9301]
dc.description.sponsorshipItalian Ministry of Instruction, University and Research (MIUR), PRIN [20109PLMH2]
dc.description.sponsorship"Fondazione Beneficentia Stiftung" Vaduz
dc.description.sponsorshipFondo di Ateneo FRA
dc.description.sponsorshipFRA
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.cis.2017.05.009
dc.identifier.issn0001-8686
dc.identifier.issn1873-3727
dc.identifier.urihttp://hdl.handle.net/10400.1/12931
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCarbon nano-onions
dc.subjectSolid lipid nanoparticles
dc.subjectNonviral gene delivery
dc.subjectTransfer radical polymerization
dc.subjectHepatocellular-carcinoma cells
dc.subjectAssembling peptide hydrogels
dc.subjectNucleic-acid delivery
dc.subjectDrug-delivery
dc.subjectIn-vivo
dc.subjectOral delivery
dc.titleRecent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage180
oaire.citation.startPage163
oaire.citation.titleAdvances in Colloid and Interface Science
oaire.citation.volume249
person.familyNameMedronho
person.givenNameBruno
person.identifier.ciencia-id6918-9AB3-8D22
person.identifier.orcid0000-0003-0972-1739
person.identifier.ridP-5927-2014
person.identifier.scopus-author-id9940656700
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication4c03571a-93da-4504-8acf-c74326449852
relation.isAuthorOfPublication.latestForDiscovery4c03571a-93da-4504-8acf-c74326449852

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