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The therapeutic potential of wogonin observed in preclinical studies

2021-06Journal article Open access
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dc.contributor.authorSharifi-Rad, Javad
dc.contributor.authorHerrera-Bravo, Jesús
dc.contributor.authorSalazar, Luis A.
dc.contributor.authorShaheen, Shabnum
dc.contributor.authorAbdulmajid Ayatollahi, Seyed
dc.contributor.authorKobarfard, Farzad
dc.contributor.authorImran, Muhammad
dc.contributor.authorImran, Ali
dc.contributor.authorCustódio, Luísa
dc.contributor.authorDolores López, María
dc.contributor.authorSchoebitz, Mauricio
dc.contributor.authorMartorell, Miquel
dc.contributor.authorKumar, Manoj
dc.contributor.authorAnsar Rasul Suleria, Hafiz
dc.contributor.authorCho, William C.
dc.date.accessioned2021-07-20T12:57:03Z
dc.date.available2021-07-20T12:57:03Z
dc.date.issued2021-06
dc.description.abstractWogonin is a flavonoid found in different plants such as roots of Scutellaria baicalensis Georgi distributed mainly in Asia and Europe. Dried root extracts of S. baicalensis with high content of wogonin, popularly known as "Huang-Qin" or Chinese or baical skullcap, have been used for long time in traditional Chinese medicine. Several health benefits are attributed to wogonin and derivatives showing anti-inflammatory, antiviral, anticancer, and antioxidant effects and more recently antineurodegenerative properties. Preclinical pharmacological activities of wogonin against diverse types of cancer such as breast, colorectal, and human gastric cancer will be presented in this review. In addition, studies on oxidative stress and bioavailability of wogonin will be discussed together with antineurodegenerative potential with special focus on Alzheimer's disease. Outcomes extracted from the last preclinical studies related to therapeutic applications of wogonin will be commented and updated in this review. The scientific evidence collected in this review aims to encourage transfer of the preclinical evidence of wogonin to new clinical studies.pt_PT
dc.description.sponsorshipCONICYT PIA/APOYO CCTE: AFB170007pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1155/2021/9935451pt_PT
dc.identifier.eissn1741-4288
dc.identifier.urihttp://hdl.handle.net/10400.1/16788
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawipt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSynthase de óxido nítricopt_PT
dc.subjectNeurônios de gânglio raizpt_PT
dc.subjectEstresse induzidopt_PT
dc.subjectScutellaria- Baicalensispt_PT
dc.subjectRadix-Scutellariaept_PT
dc.subjectFlavone vegetalpt_PT
dc.subjectPlasma de ratopt_PT
dc.subjectIn vitropt_PT
dc.subjectBaicalinapt_PT
dc.titleThe therapeutic potential of wogonin observed in preclinical studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage9pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleEvidence-Based Complementary and Alternative Medicinept_PT
oaire.citation.volume2021pt_PT
person.familyNameCustódio
person.givenNameLuísa
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id15831018900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf9cfed0f-6b67-413e-988c-ac7397183471
relation.isAuthorOfPublication.latestForDiscoveryf9cfed0f-6b67-413e-988c-ac7397183471

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