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Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration

2011-09Journal article Open access
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dc.contributor.authorSousa, Sara
dc.contributor.authorAfonso, Nuno
dc.contributor.authorBensimon-Brito, Anabela
dc.contributor.authorFonseca, Mariana
dc.contributor.authorSimões, Mariana
dc.contributor.authorLeon, Joaquin
dc.contributor.authorRoehl, Henry
dc.contributor.authorCancela, M. Leonor
dc.contributor.authorJacinto, António
dc.date.accessioned2018-12-07T14:58:16Z
dc.date.available2018-12-07T14:58:16Z
dc.date.issued2011-09
dc.description.abstractThe origin of cells that generate the blastema following appendage amputation has been a long-standing question in epimorphic regeneration studies. The blastema is thought to originate from either stem (or progenitor) cells or differentiated cells of various tissues that undergo dedifferentiation. Here, we investigate the origin of cells that contribute to the regeneration of zebrafish caudal fin skeletal elements. We provide evidence that the process of lepidotrichia (bony rays) regeneration is initiated as early as 24 hours post-amputation and that differentiated scleroblasts acquire a proliferative state, detach from the lepidotrichia surface, migrate distally, integrate into the blastema and dedifferentiate. These findings provide novel insights into the origin of cells in epimorphic appendage regeneration in zebrafish and suggest conservation of regeneration mechanisms between fish and amphibians.
dc.description.sponsorshipFundacao para a Ciencia e Tecnologia (FCT), Portugal; FCT [PTDC/SAU-OBD/100200/2008, PTDC/SAU-OBD/73112/2006]; Ramon y Cajal; MCIN, Spain; Medical Research Council [G0700091B]
dc.identifier.doi10.1242/dev.064717
dc.identifier.issn0950-1991
dc.identifier.issn1477-9129
dc.identifier.urihttp://hdl.handle.net/10400.1/11943
dc.language.isoeng
dc.peerreviewedyes
dc.publisherCompany of Biologists
dc.relationThe role of reinnervation in tissue regeneration
dc.subjectLimb regeneration
dc.subjectHeart regeneration
dc.subjectGene-rxpression
dc.subjectSonic-hedgehog
dc.subjectDedifferentiation
dc.subjectProliferation
dc.subjectTail
dc.subjectTeleosts
dc.subjectOccurs
dc.subjectAcid
dc.subjectFin regeneration
dc.subjectSkeletal regeneration
dc.subjectBlastema formation
dc.subjectDedifferentiation
dc.subjectZebrafish
dc.titleDifferentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleThe role of reinnervation in tissue regeneration
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-OBD%2F100200%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-OBD%2F73112%2F2006/PT
oaire.citation.endPage3905
oaire.citation.issue18
oaire.citation.startPage3897
oaire.citation.titleDevelopment
oaire.citation.volume138
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
person.familyNameBensimon-Brito
person.familyNameCancela
person.givenNameAnabela
person.givenNameM. Leonor
person.identifier1460592
person.identifier.ciencia-id8419-63A7-D0E5
person.identifier.orcid0000-0003-1663-2232
person.identifier.orcid0000-0003-3114-6662
person.identifier.ridN-7291-2014
person.identifier.scopus-author-id36154529200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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relation.isAuthorOfPublicationb9bbfe32-3dfe-4131-ad14-a4394008447f
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