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Developmental effects of warfin in the skeletogenesis of zebrafish (Danio rerio) larvae
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Resumo(s)
The vitamin K-dependent gamma carboxylase (VKGC) is responsible for the post-translational modification of glutamate residues to y-carboxy glumatic acid (Gla), in the presence of the co-factor, vitamin K. This modification has important implications, such as physiological
homeostasis, signal transduction and bone calcification. This mechanism ensures complete carboxylation of coagulation factors, and matrix proteins like bone Gla protein (bgp) and matrix Gla protein (mgp), being essential for their biological activity.
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Contexto Educativo
Citação
Peres dos Santos R., Brito A.B., Cancela M.L., Gavaia P.J. 2008. Developmental effects of warfarin in the skeletogenesis of zebrafish (Danio rerio) larvae. Marine Genomics Europe final meeting. CCMAR-University of Algarve May 13-16, Faro, Portugal.