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Numb/Numbl-Opo antagonism controls retinal epithelium morphogenesis by regulating integrin endocytosis

2012-10-16Journal article Restricted access
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dc.contributor.authorBogdanović, Ozren
dc.contributor.authorDelfino-Machín, Mariana
dc.contributor.authorNicolás-Pérez, María
dc.contributor.authorGavilán, María P.
dc.contributor.authorI, Gago-Rodrigues
dc.contributor.authorFernández-Miñán, Ana
dc.contributor.authorLillo, Concepción
dc.contributor.authorRíos, Rosa M.
dc.contributor.authorWittbrodt, Joachim
dc.contributor.authorMartínez-Morales, Juan R.
dc.date.accessioned2017-01-20T14:04:09Z
dc.date.available2017-01-20T14:04:09Z
dc.date.issued2012-10-16
dc.description.abstractPolarized trafficking of adhesion receptors plays a pivotal role in controlling cellular behavior during morphogenesis. Particularly, clathrin-dependent endocytosis of integrins has long been acknowledged as essential for cell migration. However, little is known about the contribution of integrin trafficking to epithelial tissue morphogenesis. Here we show how the transmembrane protein Opo, previously described for its essential role during optic cup folding, plays a fundamental role in this process. Through interaction with the PTB domain of the clathrin adaptors Numb and Numbl via an integrin-like NPxF motif, Opo antagonizes Numb/Numbl function and acts as a negative regulator of integrin endocytosis in vivo. Accordingly, numb/numbl gain-of-function experiments in teleost embryos mimic the retinal malformations observed in opo mutants. We propose that developmental regulator Opo enables polarized integrin localization by modulating Numb/Numbl, thus directing the basal constriction that shapes the vertebrate retina epithelium.pt_PT
dc.description.sponsorshipGrants BFU2008-04362 and BFU2011-22916; JuandelaCierva(Espanha); Intramural/CSIC’’ 200920I212(Espanha); FCT(Portugal)
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.devcel.2012.09.004pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.1/8966
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCell Presspt_PT
dc.subjectAnimalspt_PT
dc.subjectCellspt_PT
dc.subjectFish proteinspt_PT
dc.subjectHeLa cellspt_PT
dc.subjectHumanspt_PT
dc.subjectIntegrinspt_PT
dc.subjectMembrane proteinspt_PT
dc.subjectNerve tissue proteinspt_PT
dc.subjectOryziaspt_PT
dc.subjectRetinal pigment epitheliumpt_PT
dc.subjectEndocytosispt_PT
dc.titleNumb/Numbl-Opo antagonism controls retinal epithelium morphogenesis by regulating integrin endocytosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage795pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage782pt_PT
oaire.citation.titleDevelopmental Cellpt_PT
oaire.citation.volume23pt_PT
person.familyNameGago Rodrigues
person.givenNameInês
person.identifier.ciencia-id5019-5D4A-15B8
person.identifier.orcid0000-0002-9745-0467
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0e1f7ddd-5169-4522-a1cf-966e4e75a164
relation.isAuthorOfPublication.latestForDiscovery0e1f7ddd-5169-4522-a1cf-966e4e75a164

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