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Molecularly defined sinonasal malignancies: an overview with focus on the current WHO classification and recently described provisional entities

2024Journal article Open access
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dc.contributor.authorSkálová, Alena
dc.contributor.authorAgaimy, Abbas
dc.contributor.authorBradova, Martina
dc.contributor.authorPoorten, Vincent Vander
dc.contributor.authorHanna, Ehab
dc.contributor.authorGuntinas-Lichius, Orlando
dc.contributor.authorFranchi, Alessandro
dc.contributor.authorHellquist, Henrik
dc.contributor.authorSimpson, Roderick H. W.
dc.contributor.authorLopéz, Fernando
dc.contributor.authorNuyts, Sandra
dc.contributor.authorChiesa-Estomba, Carlos
dc.contributor.authorNg, Sweet Ping
dc.contributor.authorHomma, Akihiro
dc.contributor.authorTeng, Yong
dc.contributor.authorLeivo, Ilmo
dc.contributor.authorFerlito, Alfio
dc.date.accessioned2024-04-11T11:46:47Z
dc.date.available2024-04-11T11:46:47Z
dc.date.issued2024
dc.description.abstractClassification of tumors of the head and neck has evolved in recent decades including a widespread application of molecular testing in tumors of the sinonasal tract, salivary glands, and soft tissues with a predilection for the head and neck. The availability of new molecular techniques has allowed for the definition of multiple novel tumor types unique to head and neck sites. Moreover, an expanding spectrum of immunohistochemical markers specific to genetic alterations facilitates rapid identification of diagnostic molecular abnormalities. As such, it is currently possible for head and neck pathologists to benefit from a molecularly defined tumor classification while making diagnoses that are still based largely on histopathology and immunohistochemistry. This review covers the principal molecular alterations in sinonasal malignancies, such as alterations in DEK, AFF2, NUTM1, IDH1-2, and SWI/SNF genes in particular, that are important from a practical standpoint for diagnosis, prognosis, and prediction of response to treatment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s00428-024-03775-ypt_PT
dc.identifier.issn0945-6317
dc.identifier.urihttp://hdl.handle.net/10400.1/20626
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSinonasal tumorpt_PT
dc.subjectSinonasalpt_PT
dc.subjectSoft tissuept_PT
dc.subjectHead and neck · Molecular diagnostics · Next-generation sequencingpt_PT
dc.subjectHead and neckpt_PT
dc.subjectMolecular diagnosticspt_PT
dc.subjectNext-generation sequencingpt_PT
dc.titleMolecularly defined sinonasal malignancies: an overview with focus on the current WHO classification and recently described provisional entitiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleVirchows Archivpt_PT
person.familyNameHellquist
person.givenNameHenrik
person.identifier.ciencia-id9C11-221B-93BF
person.identifier.orcid0000-0003-3044-6065
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione632b82a-cf09-4f9a-b445-9d9a9de47438
relation.isAuthorOfPublication.latestForDiscoverye632b82a-cf09-4f9a-b445-9d9a9de47438

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