Repository logo
 
Publication

Acclimation of oxygenic photosynthesis to iron starvation is controlled by the sRNA IsaR1

2017-05Journal article Open Access
Simple item page
dc.contributor.authorGeorg, Jens
dc.contributor.authorKostova, Gergana
dc.contributor.authorVuorijoki, Linda
dc.contributor.authorSchoen, Verena
dc.contributor.authorKadowaki, Taro
dc.contributor.authorHuokko, Tuomas
dc.contributor.authorBaumgartner, Desiree
dc.contributor.authorMueller, Maximilian
dc.contributor.authorKlaehn, Stephan
dc.contributor.authorAllahverdiyeva, Yagut
dc.contributor.authorHihara, Yukako
dc.contributor.authorFutschik, Matthias
dc.contributor.authorAro, Eva-Mari
dc.contributor.authorHess, Wolfgang R.
dc.date.accessioned2019-11-20T15:07:35Z
dc.date.available2019-11-20T15:07:35Z
dc.date.issued2017-05
dc.description.abstractOxygenic photosynthesis crucially depends on proteins that possess Fe (2+) or Fe/S complexes as co-factors or prosthetic groups. Here, we show that the small regulatory RNA (sRNA) IsaR1 (Iron-Stress-Activated RNA 1) plays a pivotal role in acclimation to low-iron conditions. The IsaR1 regulon consists of more than 15 direct targets, including Fe (2+)-containing proteins involved in photosynthetic electron transfer, detoxification of anion radicals, citrate cycle, and tetrapyrrole biogenesis. IsaR1 is essential for maintaining physiological levels of Fe/S cluster biogenesis proteins during iron deprivation. Consequently, IsaR1 affects the acclimation of the photosynthetic apparatus to iron starvation at three levels: (1) directly, via posttranscriptional repression of gene expression; (2) indirectly, via suppression of pigment; and (3) Fe/S cluster biosynthesis. Homologs of IsaR1 are widely conserved throughout the cyanobacterial phylum. We conclude that IsaR1 is a critically important riboregulator. These findings provide a new perspective for understanding the regulation of iron homeostasis in photosynthetic organisms.
dc.description.sponsorshipGerman Federal Ministry of Education and Research [0316165]
dc.description.sponsorshipDFG [HE 2544/9-1]
dc.description.sponsorshipAcademy of Finland [253269, 271832, 273870]
dc.description.sponsorshipPortuguese Fundacao para a Ciencia e a Tecnologia [IF/00881/2013, UID/Multi/04326/2013-CCMAR]
dc.description.sponsorshipEuropean Commission FP7 Marie Curie Initial Training Network "Photo.COMM'' [317184]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.cub.2017.04.010
dc.identifier.issn0960-9822
dc.identifier.issn1879-0445
dc.identifier.urihttp://hdl.handle.net/10400.1/13119
dc.language.isoeng
dc.peerreviewedyes
dc.publisherCell Press
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSp Pcc 6803
dc.subjectSynechococcus Sp Pcc7942
dc.subjectEscherichia-coli
dc.subjectElectron-transport
dc.subjectStress responses
dc.subjectSufbcds operon
dc.subjectPhotosystem-I
dc.subjectCyanobacterium
dc.subjectChlorophyll
dc.subjectDeficiency
dc.titleAcclimation of oxygenic photosynthesis to iron starvation is controlled by the sRNA IsaR1
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT
oaire.citation.endPage+
oaire.citation.issue10
oaire.citation.startPage1425
oaire.citation.titleCurrent Biology
oaire.citation.volume27
oaire.fundingStream5876
person.familyNameFutschik
person.givenNameMatthias
person.identifier.ciencia-idA71B-AD01-3501
person.identifier.orcid0000-0002-6245-8071
person.identifier.scopus-author-id14017989400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationd58f3269-c7e1-4c22-b094-5cfe6750821b
relation.isAuthorOfPublication.latestForDiscoveryd58f3269-c7e1-4c22-b094-5cfe6750821b
relation.isProjectOfPublication868b4818-3efa-4edb-9202-c464d64fd38f
relation.isProjectOfPublication.latestForDiscovery868b4818-3efa-4edb-9202-c464d64fd38f

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Acclimation of Oxygenic - 13119.pdf
Size:
4.26 MB
Format:
Adobe Portable Document Format
Download

Collections

CCM2-Artigos (em revistas ou actas indexadas)