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Predictability modulates the affective and sensory-discriminative neural processing of pain

2006-10Journal article Open access
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dc.contributor.authorCarlsson, Katrina
dc.contributor.authorAndersson, Jesper
dc.contributor.authorPetrovic, Predrag
dc.contributor.authorPetersson, Karl Magnus
dc.contributor.authorOhman, Arne
dc.contributor.authorIngvar, Martin
dc.date.accessioned2018-12-07T14:58:06Z
dc.date.available2018-12-07T14:58:06Z
dc.date.issued2006-10
dc.description.abstractKnowing what is going to happen next, that is, the capacity to predict upcoming events, modulates the extent to which aversive stimuli induce stress and anxiety. We explored this issue by manipulating the temporal predictability of aversive events by means of a visual cue, which was either correlated or uncorrelated with pain stimuli (electric shocks). Subjects reported lower levels of anxiety, negative valence and pain intensity when shocks were predictable. In addition to attenuate focus on danger, predictability allows for correct temporal estimation of, and selective attention to, the sensory input. With functional magnetic resonance imaging, we found that predictability was related to enhanced activity in relevant sensory-discriminative processing areas, such as the primary and secondary sensory cortex and posterior insula. In contrast, the unpredictable more aversive context was correlated to brain activity in the anterior insula and the orbitofrontal cortex, areas associated with affective pain processing. This context also prompted increased activity in the posterior parietal cortex and lateral prefrontal cortex that we attribute to enhanced alertness and sustained attention during unpredictability. (c) 2006 Elsevier Inc. All rights reserved.
dc.description.sponsorshipThis study was supported by grants from The Swedish Research Council (2003-5810), The family Hedlund Foundation and Karolinska Institutet. The project was finished in the context of Stockholm Brain Institute.
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1016/j.neuroimage.2006.05.027
dc.identifier.issn1053-8119
dc.identifier.urihttp://hdl.handle.net/10400.1/11860
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.subjectOrbitofrontal cortex
dc.subjectAnterior cingulate
dc.subjectRhesus monkey
dc.subjectTrial Fmri
dc.subjectFear
dc.subjectAnxiety
dc.subjectBrain
dc.subjectAttention
dc.subjectAmygdala
dc.subjectAwareness
dc.titlePredictability modulates the affective and sensory-discriminative neural processing of pain
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1814
oaire.citation.issue4
oaire.citation.startPage1804
oaire.citation.titleNeuroimage
oaire.citation.volume32
person.familyNamePetersson
person.familyNameIngvar
person.givenNameKarl Magnus
person.givenNameMartin
person.identifier13089
person.identifier.ciencia-id6D14-B1D1-1532
person.identifier.orcid0000-0002-8245-0392
person.identifier.orcid0000-0002-9041-5714
person.identifier.ridE-8188-2012
person.identifier.scopus-author-id7006470225
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication0f437ab3-c630-40ad-963f-13196ad4fbd6
relation.isAuthorOfPublication01e2fd8c-2e05-44e7-afdd-31a53a20d147
relation.isAuthorOfPublication.latestForDiscovery0f437ab3-c630-40ad-963f-13196ad4fbd6

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