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The tumorigenic roles of the cellular REDOX regulatory systems

2016Journal article Open access
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dc.contributor.authorCastaldo, Stéphanie Anais
dc.contributor.authorFreitas, Joana Raquel
dc.contributor.authorConchinha, Nadine Vasconcelos
dc.contributor.authorMadureira, Patrícia A.
dc.date.accessioned2017-04-07T15:57:41Z
dc.date.available2017-04-07T15:57:41Z
dc.date.issued2016
dc.description.abstractThe cellular REDOX regulatory systems play a central role in maintaining REDOX homeostasis that is crucial for cell integrity, survival, and proliferation. To date, a substantial amount of data has demonstrated that cancer cells typically undergo increasing oxidative stress as the tumor develops, upregulating these important antioxidant systems in order to survive, proliferate, and metastasize under these extreme oxidative stress conditions. Since a large number of chemotherapeutic agents currently used in the clinic rely on the induction of ROS overload or change of ROS quality to kill the tumor, the cancer cell REDOX adaptation represents a significant obstacle to conventional chemotherapy. In this review we will first examine the different factors that contribute to the enhanced oxidative stress generally observed within the tumor microenvironment. We will then make a comprehensive assessment of the current literature regarding the main antioxidant proteins and systems that have been shown to be positively associated with tumor progression and chemoresistance. Finally we will make an analysis of commonly used chemotherapeutic drugs that induce ROS. The current knowledge of cancer cell REDOX adaptation raises the issue of developing novel and more effective therapies for these tumors that are usually resistant to conventional ROS inducing chemotherapy.
dc.identifier.doi10.1155/2016/8413032
dc.identifier.otherAUT: PAM02765;
dc.identifier.urihttp://hdl.handle.net/10400.1/9788
dc.language.isoeng
dc.peerreviewedyes
dc.publisherLandes Bioscience
dc.relationWORK PLAN FOR RESEARCH FELLOWSHIP PCOFUND-GA-2009-246542
dc.relation.isbasedonMEDLINE:26682014
dc.titleThe tumorigenic roles of the cellular REDOX regulatory systems
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleWORK PLAN FOR RESEARCH FELLOWSHIP PCOFUND-GA-2009-246542
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBI%2F52182%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBCC%2F105831%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.citation.endPage8413032
oaire.citation.startPage8413032
oaire.citation.titleOxidative medicine and cellular longevity
oaire.citation.volume2016
oaire.fundingStreamSFRH
oaire.fundingStream5876
person.familyNameMadureira
person.givenNamePatricia
person.identifier.ciencia-id6612-9A86-6929
person.identifier.orcid0000-0002-4856-3908
person.identifier.scopus-author-id10340140500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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relation.isAuthorOfPublication.latestForDiscoverya40de6a3-d52d-45dd-8620-cb94a22ebc8f
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