Repository logo
 
Publication

The intestinal proteome of diabetic and control children is enriched with different microbial and host proteins

2016-12Journal article Restricted access
Simple item page
dc.contributor.authorPinto, Elsa
dc.contributor.authorAnselmo, Marisol
dc.contributor.authorCalha, Maria
dc.contributor.authorBottrill, Andrew
dc.contributor.authorDuarte, Isabel
dc.contributor.authorAndrew, Peter
dc.contributor.authorFaleiro, Leonor
dc.date.accessioned2017-04-07T15:55:33Z
dc.date.available2017-04-07T15:55:33Z
dc.date.issued2016-12
dc.description.abstractIn this study the intestinal microbial proteome of children with established type 1 diabetes (T1D) was compared with the proteome of healthy children (Control) with the aim to identify differences in the activity of the intestinal microbiota that will not only contribute to a deeper knowledge of the functionality of the gut in these children but may also provide new approaches to improve the Control of the disease. Fecal protein extracts collected from three T1D children (aged of 9.3 - 0.6) and three Control children (aged of 9.3 - 1.5) were analyzed using a combination of two-dimensional gel electrophoresis (2-DE) and spectral counting. The results evidenced markedly differences between the intestinal proteome of T1D children and the Control. The T1D microbial intestinal proteome was enriched with proteins of clostridial cluster XVa and cluster IV and Bacteroides. In contrast, the Control proteome was enriched with bifidobacterial proteins. In both groups proteins with moonlight function were observed. Human proteins also distinguished the two groups with T1D children depleted in exocrine pancreatic enzymes.
dc.identifier.doi10.1099/mic.0.000412
dc.identifier.issn1350-0872
dc.identifier.urihttp://hdl.handle.net/10400.1/9159
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMicrobiology Society
dc.relationPAPEL FISIOLÓGICO DA MICROBIOTA INTESTINAL EM CRIANÇAS COM DIABETES TIPO 1
dc.relationStrategic Project - LA 23 - 2011-2012
dc.relation.isbasedonMEDLINE:27983481
dc.titleThe intestinal proteome of diabetic and control children is enriched with different microbial and host proteins
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePAPEL FISIOLÓGICO DA MICROBIOTA INTESTINAL EM CRIANÇAS COM DIABETES TIPO 1
oaire.awardTitleStrategic Project - LA 23 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F66954%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0023%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FEQB%2FLA0023%2F2013/PT
oaire.citation.titleMicrobiology
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
person.familyNameFélix Calha
person.familyNamedos Santos Duarte
person.familyNameFaleiro
person.givenNameMaria Manuela
person.givenNameGuilhermina Isabel
person.givenNameMaria Leonor
person.identifier252666
person.identifier.ciencia-id3012-9A19-5CB2
person.identifier.ciencia-idED15-7F67-7B64
person.identifier.ciencia-id281D-5E01-F09A
person.identifier.orcid0000-0002-1470-6181
person.identifier.orcid0000-0003-0060-2936
person.identifier.orcid0000-0002-3878-6948
person.identifier.scopus-author-id6507927018
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication4f5a57d9-4969-4b52-b3e5-b46f945de649
relation.isAuthorOfPublication6e1e1dd4-e2b4-4dfa-b7d7-f7990e9bd179
relation.isAuthorOfPublication5361e29a-3b79-4ce8-9f87-0c667d60588d
relation.isAuthorOfPublication.latestForDiscovery5361e29a-3b79-4ce8-9f87-0c667d60588d
relation.isProjectOfPublicationfd447e6a-3d9c-44e8-9739-30a241abd426
relation.isProjectOfPublication999ecdf9-ae2c-45f8-96bc-218962b40270
relation.isProjectOfPublication89fcacba-95e1-424f-aee5-1a0bdc3d7303
relation.isProjectOfPublication.latestForDiscovery89fcacba-95e1-424f-aee5-1a0bdc3d7303

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
9159.pdf
Size:
1.18 MB
Format:
Adobe Portable Document Format
Download

Collections

FCT2-Artigos (em revistas ou actas indexadas)
FCB2-Artigos (em revistas ou actas indexadas)
ULS2-Artigos (em revistas ou actas indexadas)