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Microspheres loaded with polysaccharide nanoparticles for pulmonary delivery: preparation, structure and surface analysis

dc.contributor.authorAl-Qadi, Sonia
dc.contributor.authorGrenha, Ana
dc.contributor.authorRemuñán-López, Carmen
dc.date.accessioned2013-01-15T15:32:59Z
dc.date.available2013-01-15T15:32:59Z
dc.date.issued2011
dc.description.abstractIn this work, we report the preparation of a nanoparticle-based dry powder for pulmonary administration. Hybrid chitosan/hyaluronic acid nanoparticles were produced by ionotropic gelation and characterized for their physicochemical properties, being further studied by solid nuclear magnetic resonance (NMR). Using mannitol as carrier, nanoparticles were microencapsulated by spray drying, resulting in a dry powder with appropriate aerodynamic properties for lung delivery. In order to investigate the nanoparticles distribution within the carrier matrix, several techniques were applied that permitted an in-depth analysis of the system structure and surface, such as confocal laser scanning microscopy (CLSM) and X-ray photoelectron spectroscopy (XPS) in combination with time-of-flight secondary ion mass spectroscopy (TOF-SIMS). Overall, the studies conducted revealed that nanoparticles are homogeneously distributed through mannitol microspheres, suggesting the success of the microencapsulation process. In the light of these findings, it was concluded that the developed delivery system holds great potential for lung delivery of macromolecules.por
dc.identifier.issn0144-8617
dc.identifier.otherAUT: AMG02212;
dc.identifier.urihttp://hdl.handle.net/10400.1/2082
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectChitosanpor
dc.subjectHyaluronic acidpor
dc.subjectMicrospherespor
dc.subjectNanoparticlespor
dc.subjectPulmonary administrationpor
dc.subjectSpray-dryingpor
dc.subjectTOF-SIMSpor
dc.subjectXPSpor
dc.titleMicrospheres loaded with polysaccharide nanoparticles for pulmonary delivery: preparation, structure and surface analysispor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage34por
oaire.citation.startPage25por
oaire.citation.titleCarbohydrate Polymerspor
oaire.citation.volume86por
person.familyNameGrenha
person.givenNameAna
person.identifier.ciencia-id091C-0D58-7225
person.identifier.orcid0000-0002-2136-1396
person.identifier.ridH-1392-2017
person.identifier.scopus-author-id8607930100
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication1bd4d8f1-40e5-45af-b1e8-4b8e73a6a70d
relation.isAuthorOfPublication.latestForDiscovery1bd4d8f1-40e5-45af-b1e8-4b8e73a6a70d

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