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Stanniocalcin 1 effects on the renal gluconeogenesis pathway in rat and fish

2015-10Journal article Open access
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dc.contributor.authorSchein, Vanessa
dc.contributor.authorKucharski, Luiz C.
dc.contributor.authorM Guerreiro, Pedro
dc.contributor.authorMartins, Tiago Leal
dc.contributor.authorMorgado, Isabel
dc.contributor.authorPower, Deborah M.
dc.contributor.authorCanario, Adelino V. M.
dc.contributor.authorda Silva, Roselis S. M.
dc.date.accessioned2018-12-07T14:58:07Z
dc.date.available2018-12-07T14:58:07Z
dc.date.issued2015-10
dc.description.abstractThe mammalian kidney contributes significantly to glucose homeostasis through gluconeogenesis. Considering that stanniocalcin 1 (STC1) regulates ATP production, is synthesized and acts in different cell types of the nephron, the present study hypothesized that STC1 may be implicated in the regulation of gluconeogenesis in the vertebrate kidney. Human STC1 strongly reduced gluconeogenesis from C-14-glutamine in rat renal medulla (MD) slices but not in renal cortex (CX), nor from C-14-lactic acid. Total PEPCK activity was markedly reduced by hSTC1 in MD but not in CX. Pck2 (mitochondrial PEPCK isoform) was down-regulated by hSTC1 in MD but not in CX. In fish (Dicentrarchus labrax) kidney slices, both STC1-A and -B isoforms decreased gluconeogenesis from C-14-acid lactic, while STC1-A increased gluconeogenesis from C-14-glutamine. Overall, our results demonstrate a role for STC1 in the control of glucose synthesis via renal gluconeogenesis in mammals and suggest that it may have a similar role in teleost fishes. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) Brazil; Foundation for Science and Technology of Portugal [PTDC/MAR/121279/2010]; bilateral programme CAPES (Brazil)/GRICES (Portugal) CAPES/GRICES [215/08]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.mce.2015.07.010
dc.identifier.issn0303-7207
dc.identifier.urihttp://hdl.handle.net/10400.1/11869
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCarbohydrate-rich diets
dc.subjectGene-expression
dc.subjectPhosphoenolpyruvate carboxykinase
dc.subjectGlucose-homeostasis
dc.subjectProximal tubule
dc.subjectRainbow-trout
dc.subjectGlutamine-metabolism
dc.subjectHormonal-regulation
dc.subjectAmmonia production
dc.subjectTransgenic mice
dc.titleStanniocalcin 1 effects on the renal gluconeogenesis pathway in rat and fish
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage8
oaire.citation.issueC
oaire.citation.startPage1
oaire.citation.titleMolecular and Cellular Endocrinology
oaire.citation.volume414
person.familyNameSchein
person.familyNameGuerreiro
person.familyNameMorgado
person.familyNamePower
person.familyNameCanario
person.givenNameVanessa
person.givenNamePedro Miguel
person.givenNameIsabel
person.givenNameDeborah Mary
person.givenNameAdelino
person.identifierA-2539-2009
person.identifier143624
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person.identifier.orcid0000-0001-7276-5772
person.identifier.orcid0000-0001-5371-7919
person.identifier.orcid0000-0002-7826-997X
person.identifier.orcid0000-0003-1366-0246
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridA-3025-2014
person.identifier.ridJ-4798-2013
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id6603316805
person.identifier.scopus-author-id18134268300
person.identifier.scopus-author-id7101806760
person.identifier.scopus-author-id56568523700
rcaap.rightsopenAccess
rcaap.typearticle
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