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Improving the heterotrophic media of three chlorella vulgaris mutants toward optimal color, biomass and protein productivity

2025-07-02Artigo científico Acesso aberto
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datacite.subject.sdg02:Erradicar a Fome
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
dc.contributor.authorTrovão dos Santos, Mafalda
dc.contributor.authorCunha, Miguel
dc.contributor.authorSanto, Gonçalo Espírito
dc.contributor.authorPedroso, Humberto
dc.contributor.authorReis, Ana
dc.contributor.authorBarros, Ana
dc.contributor.authorCorreia, Nádia
dc.contributor.authorSchüler, Lisa
dc.contributor.authorCosta, Monya
dc.contributor.authorFerreira, Sara
dc.contributor.authorCardoso, Helena
dc.contributor.authorVentura, Márcia
dc.contributor.authorVarela, João
dc.contributor.authorSilva, Joana
dc.contributor.authorFreitas, Filomena
dc.contributor.authorPereira, Hugo
dc.date.accessioned2026-03-10T14:11:04Z
dc.date.available2026-03-10T14:11:04Z
dc.date.issued2025-07-02
dc.description.abstractThe high production costs and unappealing sensory properties still limit the widespread commercialization of microalgae feedstocks. Therefore, this work focused on fine-tuning the heterotrophic medium composition to cultivate novel green, yellow, and white Chlorella vulgaris mutant strains. Screening assays were carried out to select the most significant factors, and different nutrient concentrations were optimized by modelling biomass and protein productivity, specific growth rate, and color, via response surface methodology. The biomass and protein productivities achieved by these strains were improved by up to 70% and 94%, respectively. Additionally, biomass color was correlated with medium composition for the first time, allowing the improvement of the yellow and white mutant colorations by 20%. Overall, the findings of this study are vital to overcoming the challenges of the biobased industry, allowing the enhancement of the cost-effectiveness, attractiveness, and nutritional profiles of microalgae-based products in different markets and applications.eng
dc.description.sponsorship2020.06814.BD PhD and 2020.07229.BD; Grant (2020.06814.BDANA)
dc.identifier.doi10.1038/s41598-025-05913-1
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.1/28399
dc.language.isoeng
dc.peerreviewedyes
dc.publisherNature Research
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationInstitute for Health and Bioeconomy
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relation.ispartofScientific Reports
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBiomass color
dc.subjectBiomass and protein productivity
dc.subjectCulture medium optimization
dc.subjectMicroalgae
dc.subjectRandom mutagenesis
dc.subjectSurface response methodology
dc.titleImproving the heterotrophic media of three chlorella vulgaris mutants toward optimal color, biomass and protein productivityeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDP/04378/2020
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oaire.awardNumberLA/P/0140/2020
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oaire.awardNumberLA/P/0101/2020
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleInstitute for Health and Bioeconomy
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
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oaire.citation.issue1
oaire.citation.startPage23325
oaire.citation.titleScientific Reports
oaire.citation.volume15
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person.identifier.orcid0000-0003-3977-7418
person.identifier.orcid0000-0002-1369-2099
person.identifier.ridM-4223-2013
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