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High diversity of pathogenic Escherichia coli clones carrying mcr‐1 among gulls underlines the need for strategies at the environment–livestock–human interface

2022Journal article Restricted access
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dc.contributor.authorRibeiro‐Almeida, Marisa
dc.contributor.authorMourão, Joana
dc.contributor.authorNovais, Ângela
dc.contributor.authorPereira, Sofia
dc.contributor.authorFreitas‐Silva, Joana
dc.contributor.authorRibeiro, Sofia
dc.contributor.authorMartins da Costa, Paulo
dc.contributor.authorPeixe, Luísa
dc.contributor.authorAntunes, Patrícia
dc.date.accessioned2022-12-07T11:35:32Z
dc.date.available2022-12-07T11:35:32Z
dc.date.issued2022
dc.description.abstractThe expansion of mcr-carrying bacteria is a well-recognized public health problem. Measures to contain mcr spread have mainly been focused on the food-animal production sector. Nevertheless, the spread of MCR producers at the environmental interface particularly driven by the increasing population of gulls in coastal cities has been less explored. Occurrence of mcr-carrying Escherichia coli in gull's colonies faeces on a Portuguese beach was screened over 7 months. Cultural, molecular and genomic approaches were used to characterize their diversity, mcr plasmids and adaptive features. Multidrug-resistant mcr-1-carrying E. coli were detected for 3 consecutive months. Over time, multiple strains were recovered, including zoonotic-related pathogenic E. coli clones (e.g. B2-ST131-H22, A-ST10 and B1-ST162). Diverse mcr-1 genetic environments were mainly associated with ST2/ST4-HI2 (ST10, ST131, ST162, ST354 and ST4204) but also IncI2 (ST12990) plasmids or in the chromosome (ST656). Whole-genome sequencing revealed enrichment of these strains on antibiotic resistance, virulence and metal tolerance genes. Our results underscore gulls as important spreaders of high-priority bacteria and genes that may affect the environment, food-animals and/or humans, potentially undermining One-Health strategies to reduce colistin resistance.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1111/1462-2920.16111pt_PT
dc.identifier.issn1462-2912
dc.identifier.urihttp://hdl.handle.net/10400.1/18597
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationSafestFood: understanding the role of metals zinc and copper in the emergence and spread of mobilized-colistin-resistance MCR in food-animal production
dc.relationNot Available
dc.relationDeciphering surface glycans signatures of multidrug resistant bacterial pathogens
dc.titleHigh diversity of pathogenic Escherichia coli clones carrying mcr‐1 among gulls underlines the need for strategies at the environment–livestock–human interfacept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSafestFood: understanding the role of metals zinc and copper in the emergence and spread of mobilized-colistin-resistance MCR in food-animal production
oaire.awardTitleNot Available
oaire.awardTitleDeciphering surface glycans signatures of multidrug resistant bacterial pathogens
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F146405%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/DL 57%2F2016/DL 57%2F2016%2FCP1346%2FCT0032/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.02252.CEECIND%2FCP1662%2FCT0009/PT
oaire.citation.endPage4713pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage4702pt_PT
oaire.citation.titleEnvironmental Microbiologypt_PT
oaire.citation.volume24pt_PT
oaire.fundingStreamPOR_NORTE
oaire.fundingStreamDL 57/2016
oaire.fundingStreamCEEC IND4ed
person.familyNameCordeiro Melro Mourão
person.givenNameJoana Vanessa
person.identifierN-9035-2015
person.identifier.ciencia-id581B-E51E-CC83
person.identifier.orcid0000-0002-1296-5964
person.identifier.scopus-author-id57192482345
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery0498a745-08cf-4618-9897-4bb9cf6844d6
relation.isProjectOfPublicationeed38493-f0e8-4755-b896-b62e9eb1908a
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