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Depressive symptomatology, temperament and oxytocin serum levels in a sample of healthy female university students

2022-02-22Journal article Open access
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dc.contributor.authorVeiga, L.
dc.contributor.authorCarolino, E.
dc.contributor.authorSantos, I.
dc.contributor.authorVeríssimo, C.
dc.contributor.authorAlmeida, A.
dc.contributor.authorGrilo, A.
dc.contributor.authorBrito, M.
dc.contributor.authorSantos, M. C.
dc.date.accessioned2022-03-09T15:37:36Z
dc.date.available2022-03-09T15:37:36Z
dc.date.issued2022-02-22
dc.date.updated2022-03-01T05:03:12Z
dc.description.abstractBackground Depressive symptomatology is prevalent among female university students with adverse effects on their quality of life and academic performance. Previous research suggested associations between depressive symptomatology and oxytocin levels and between depressive symptomatology and Temperament Traits. Despite this evidence, to the best of our knowledge no research has studied the effects fboth oxytocin serum levels and temperament dimensions on depressivesymptoms in a healthy sample. The present study aimed to analyse the effect of oxytocin levels and temperament traits on depressive symptomatology in healthy female university students. Methods All participants completed the Beck Depression Inventory and the Adult Temperament Questionnaire. Blood samples were collected between 8 and 8H30 a.m. after 12 h of fasting and between 5 and 8 day of the menstrual cycle and serum oxytocin levels were quantified using a commercial enzyme-linked immunosorbent assay. A hierarchical multiple regression model using a stepwise method was conducted to identify predictors of depression. Results Forty-five women aged between 18 and 25 years old (19.37 ± 1.32 years) volunteered to participate in this study. Depressive symptomatology was negatively associated with oxytocin serum levels and "Negative affect" and positively associated with "Effortful control" and "Activation Control". In the final regression model, only oxytocin level was a predictor (B = − 0.090, p < 0.0001), the model explaining 65.2% of the depression variation. Oxytocin played a mediation role between "Negative affects" and Depressive symptomatology. Conclusions Our results showed that oxytocin level, rather than personality dimensions, was associated with depressive symptomatology. These results highlight the relevance of the discussion on the use of oxytocin as a biological marker of emotional and social symptoms that characterize depression.pt_PT
dc.description.sponsorshipIPL/2016/Oxitocina_ESTeSL
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMC Psychology. 2022 Feb 22;10(1):36pt_PT
dc.identifier.doi10.1186/s40359-022-00744-5pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.1/17659
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.relationHealth and Technology Research Center
dc.relationHealth and Technology Research Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectOxytocin levelspt_PT
dc.subjectDepressive symptomatologypt_PT
dc.subjectTemperament traitspt_PT
dc.subjectFemale university studentspt_PT
dc.titleDepressive symptomatology, temperament and oxytocin serum levels in a sample of healthy female university studentspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth and Technology Research Center
oaire.awardTitleHealth and Technology Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05608%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F05608%2F2020/PT
oaire.citation.issue1pt_PT
oaire.citation.startPage36pt_PT
oaire.citation.titleBMC Psychologypt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication19f919ca-4b5b-4d6c-92c7-958102c6fb97
relation.isProjectOfPublication48c45812-750b-4874-b594-92ef343c8e47
relation.isProjectOfPublication.latestForDiscovery19f919ca-4b5b-4d6c-92c7-958102c6fb97

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