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Does zinc produce reactive oxygen species in Ruditapes decussatus?

2004Journal article Restricted access
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dc.contributor.authorGeret, Florence
dc.contributor.authorBebianno, Maria João
dc.date.accessioned2020-05-08T14:13:38Z
dc.date.available2020-05-08T14:13:38Z
dc.date.issued2004
dc.description.abstractZinc is an essential trace element with many enzymatic functions that include antioxidant properties. To investigate whether an excess of Zn in the cells produces cytotoxicity or tissue damage or an imbalance in the antioxidant systems, marine clams (Ruditapes decussatus) were exposed to two sublethal Zn concentrations (100 and 1000 microg L(-1)) for 28 days. The effects of Zn on the activities of protective antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase, both total and selenium-dependent), lipid peroxidation, and metallothionein induction were followed in the gills and digestive gland of these clams. The results indicate that the effect of Zn exposure in this clam species depends not only on the tissue but also on the Zn concentration present. In the gills, catalase activity was enhanced by Zn exposure, whereas total glutathione peroxidase activity was inhibited. Lipid peroxidation occurred only in the clams exposed to the highest Zn concentration. In the digestive gland, the impact of Zn exposure on metabolic activity was less evident than in the gills. The most evident effect in both tissues was the enhancement of catalase activity by Zn exposure. Catalase and total glutathione peroxidase activities as well as lipid peroxidation are promising biomarkers to assess the effects of Zn in the gills of R. decussatus.pt_PT
dc.description.sponsorshipFundação para Ciência e a Tecnologia (FCT) of the Ministry of Science and Technology of Portugalpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ecoenv.2003.07.002pt_PT
dc.identifier.issn0147-6513
dc.identifier.urihttp://hdl.handle.net/10400.1/13860
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectAntioxidantspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectBivalviapt_PT
dc.subjectCatalasept_PT
dc.subjectGillspt_PT
dc.subjectGlutathione peroxidasept_PT
dc.subjectLipid peroxidationpt_PT
dc.subjectReactive oxygen speciespt_PT
dc.subjectWater pollutantspt_PT
dc.subjectZincpt_PT
dc.subjectEnvironmental exposurept_PT
dc.subjectAntioxidant enzymespt_PT
dc.subjectOxidative stresspt_PT
dc.subjectCellular zincpt_PT
dc.subjectMetallothioneinpt_PT
dc.subjectMetalpt_PT
dc.subjectMetabolismpt_PT
dc.subjectToxicitypt_PT
dc.subjectCadmiumpt_PT
dc.subjectDamagept_PT
dc.titleDoes zinc produce reactive oxygen species in Ruditapes decussatus?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage409pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage399pt_PT
oaire.citation.titleEcotoxicology and Environmental Safetypt_PT
oaire.citation.volume57pt_PT
person.familyNameGeret
person.familyNameBebianno
person.givenNameFlorence
person.givenNameMaria
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0003-0716-7172
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication90b06d61-f303-4155-b503-3368166b7782
relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery90b06d61-f303-4155-b503-3368166b7782

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