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Taurine depresses cardiac contractility and enhances systemic heart glucose utilization in the cuttlefish, Sepia officinalis

2016-02Journal article Restricted access
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dc.contributor.authorMacCormack, Tyson J.
dc.contributor.authorCallaghan, N. I.
dc.contributor.authorSykes, António V.
dc.contributor.authorDriedzic, W. R.
dc.date.accessioned2017-04-07T15:57:15Z
dc.date.available2017-04-07T15:57:15Z
dc.date.issued2016-02
dc.description.abstractTaurine is the most abundant amino acid in the blood of the cuttlefish, Sepia officinalis, where levels can exceed 200 mmol L-1. In mammals, intracellular taurine modulates cardiac Ca2+ handling and carbohydrate metabolism at much lower concentrations but it is not clear if it exerts similar actions in cephalopods. Blood Ca2+ levels are high in cephalopods and we hypothesized that taurine would depress cardiac Ca2+ flux and modulate contractility in systemic and branchial hearts of cuttlefish. Heart performance was assessed with an in situ perfused systemic heart preparation and contractility was evaluated using isometrically contracting systemic and branchial heart muscle rings. Stroke volume, cardiac output, and Ca2+ sensitivity were significantly lower in systemic hearts perfused with supplemental taurine (100 mmol L-1) than in controls. In muscle ring preparations, taurine impaired relaxation at high contraction frequencies, an effect abolished by supra-physiological Ca2+ levels. Taurine did not affect oxygen consumption in non-contracting systemic heart muscle, but extracellular glucose utilization was twice that of control preparations. Collectively, our results suggest that extracellular taurine depresses cardiac Ca2+ flux and potentiates glucose utilization in cuttlefish. Variations in taurine levels may represent an important mechanism for regulating cardiovascular function and metabolism in cephalopods.
dc.description.sponsorshipSEPIATECH (31-03-05-FEP-2)
dc.identifier.doi10.1007/s00360-015-0946-0
dc.identifier.issn0174-1578
dc.identifier.urihttp://hdl.handle.net/10400.1/9653
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Verlag
dc.relationTowards cephalopod aquaculture: cuttlefish as the spearhead species
dc.relation.isbasedonWOS:000368642800007
dc.subjectColeoid
dc.subject2-Aminoethanesulfonic acid
dc.subjectPerfused heart
dc.subjectBranchial heart
dc.subjectCalcium
dc.titleTaurine depresses cardiac contractility and enhances systemic heart glucose utilization in the cuttlefish, Sepia officinalis
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTowards cephalopod aquaculture: cuttlefish as the spearhead species
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00576%2F2014%2FCP1217%2FCT0002/PT
oaire.citation.endPage227
oaire.citation.issue2
oaire.citation.startPage215
oaire.citation.titleJournal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology
oaire.citation.volume186
oaire.fundingStreamInvestigador FCT
person.familyNameSykes
person.givenNameAntónio
person.identifier107454
person.identifier.ciencia-id7510-6641-5A42
person.identifier.orcid0000-0002-5207-0612
person.identifier.ridC-3609-2012
person.identifier.scopus-author-id7102626426
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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relation.isAuthorOfPublication.latestForDiscoveryb9d55f95-5de8-40cf-82a3-96ec98c91a55
relation.isProjectOfPublicationa7bbb7aa-912c-4d7f-933a-3905800d8dcf
relation.isProjectOfPublication.latestForDiscoverya7bbb7aa-912c-4d7f-933a-3905800d8dcf

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