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Combined proteomic and metallomic analyses in Scrobicularia plana clams to assess environmental pollution of estuarine ecosystems

2016-12Journal article Restricted access
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dc.contributor.authorGonzalez-Dominguez, Raúl
dc.contributor.authorSantos, Hugo Miguel
dc.contributor.authorBebianno, Maria João
dc.contributor.authorGarcia-Barrera, Tamara
dc.contributor.authorGomez-Ariza, José Luis
dc.contributor.authorCapelo, José Luis
dc.date.accessioned2017-04-07T15:55:34Z
dc.date.available2017-04-07T15:55:34Z
dc.date.issued2016-12
dc.description.abstractEstuaries are very important ecosystems with great ecological and economic value, but usually highly impacted by anthropogenic pressure. Thus, the assessment of pollution levels in these habitats is critical in order to evaluate their environmental quality. In this work, we combined complementary metallomic and proteomic approaches with the aim to monitor the effects of environmental pollution on Scrobicularia piano clams captured in three estuarine systems from the south coast of Portugal; Arade estuary, Ria Formosa and Guadiana estuary. Multi-elemental profiling of digestive glands was carried out to evaluate the differential pollution levels in the three study areas. Then, proteomic analysis by means of two-dimensional gel electrophoresis and mass spectrometry revealed twenty-one differential proteins, which could be associated with multiple toxicological mechanisms induced in environmentally stressed organisms. Accordingly, it could be concluded that the combination of different omic approaches presents a great potential in environmental research. (C) 2016 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipPOCI-01-0145-FEDER-007265; POCI-01-0145-FEDER-007728
dc.identifier.doi10.1016/j.marpolbul.2016.08.075
dc.identifier.issn0025-326X
dc.identifier.otherAUT: MBE00379;
dc.identifier.urihttp://hdl.handle.net/10400.1/9161
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationCHARACTERIZATION OF ONCOGENIC EPIDERMAL TRANSFORMATION IN THE PRESENILIN-DEFICIENT MICE BY MALDI-IMS TISSUE ANALYSIS AND TISSUE PROTEOMICS
dc.relation.isbasedonWOS:000390734600030
dc.titleCombined proteomic and metallomic analyses in Scrobicularia plana clams to assess environmental pollution of estuarine ecosystems
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCHARACTERIZATION OF ONCOGENIC EPIDERMAL TRANSFORMATION IN THE PRESENILIN-DEFICIENT MICE BY MALDI-IMS TISSUE ANALYSIS AND TISSUE PROTEOMICS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F73997%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04378%2F2013/PT
oaire.citation.endPage124
oaire.citation.issue01-fev
oaire.citation.startPage117
oaire.citation.titleMarine Pollution Bulletin
oaire.citation.volume113
oaire.fundingStreamOE
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameBebianno
person.givenNameMaria
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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relation.isAuthorOfPublication.latestForDiscovery2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
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