Structure, anti-Phytophthora and anti-tumor activities of a nortriterpenoid from the rhizome of Phlomis purpurea (Lamiaceae)

Mateus, Maria Da Conceição; Neves, Dina; Dacunha, Bruno; Laczko, Endre; Maia,  Cristiana; Teixeira, Rúben; Cravador, Alfredo

http://hdl.handle.net/10400.1/9232

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Mateus, Maria Da Conceição

Abstract(s)

To investigate bioactive compounds potentially involved in the biotic interactions exhibited by Phlomis purpurea (Lamiaceae) in rhizospheres infested with Phytophthora cinnamomi, the plant rhizome was chemically analysed. The nortriterpenoid (175)-2 alpha,3 alpha,11 alpha,23,24-pentahydroxy-19(18 -> 17)-abeo-28-norolean-12-en-18-one, was isolated and its structure was elucidated by comprehensive spectroscopic analysis, chiefly using 2D NMR experiments, and X-ray analysis. It was shown to be exuded by roots and to exhibit anti-Phytophthora and antitumor activities. (C) 2016 Published by Elsevier Ltd.