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Antioxidant, mineralogenic and osteogenic activities of Spartina alterniflora and Salicornia fragilis extracts rich in polyphenols

dc.contributor.authorRoberto, Vania Palma
dc.contributor.authorSurget, Gwladys
dc.contributor.authorLe Lann, Klervi
dc.contributor.authorMira, Sara
dc.contributor.authorTarasco, Marco
dc.contributor.authorGuérard, Fabienne
dc.contributor.authorPoupart, Nathalie
dc.contributor.authorLaizé, Vincent
dc.contributor.authorStiger-Pouvreau, Valérie
dc.contributor.authorCancela, M. Leonor
dc.date.accessioned2021-09-14T16:26:44Z
dc.date.available2021-09-14T16:26:44Z
dc.date.issued2021-08
dc.description.abstractOsteoporosis is an aging-related disease and a worldwide health issue. Current therapeutics have failed to reduce the prevalence of osteoporosis in the human population, thus the discovery of compounds with bone anabolic properties that could be the basis of next generation drugs is a priority. Marine plants contain a wide range of bioactive compounds and the presence of osteoactive phytochemicals was investigated in two halophytes collected in Brittany (France): the invasive Spartina alterniflora and the native Salicornia fragilis. Two semi-purified fractions, prepared through liquid-liquid extraction, were assessed for phenolic and flavonoid contents, and for the presence of antioxidant, mineralogenic and osteogenic bioactivities. Ethyl acetate fraction (EAF) wasrich in phenolic compounds and exhibited the highest antioxidant activity. While S. fragilis EAF only triggered a weak proliferative effect in vitro, S. alterniflora EAF potently induced extracellular matrix mineralization (7-fold at 250µg/mL). A strong osteogenic effect was also observed in vivo using zebrafish operculum assay (2.5-fold at 10µg/mL in 9-dpf larvae). Results indicate that polyphenol rich EAF of S. alterniflora has both antioxidant and bone anabolic activities. As an invasive species, this marine plant may represent a sustainable source of molecules for therapeutic applications in bone disorders.pt_PT
dc.description.sponsorshipEuropean Regional Development Fund (ERDF) through the Atlantic Area Program 2011-1/164/MARMED EAPA_151/2016/BLUEHUMAN; European Maritime and Fisheries Fund (EMFF/FEAMP) through the National Operational Programme MAR2020 MAR-02.01.01-FEAMP-0057/OSTEOMAR; European Era-Net through the Seas-Era program ANR-12-SEAS-0002-01/INVASIVES.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fnut.2021.719438pt_PT
dc.identifier.eissn2296-861X
dc.identifier.urihttp://hdl.handle.net/10400.1/17110
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntioxidantpt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectMineralizationpt_PT
dc.subjectOsteogenesispt_PT
dc.subjectOsteoporosispt_PT
dc.subjectMarine plantspt_PT
dc.titleAntioxidant, mineralogenic and osteogenic activities of Spartina alterniflora and Salicornia fragilis extracts rich in polyphenolspt_PT
dc.title.alternativeAtividades antioxidantes, mineralogênicas e osteogênicas de Spartina alterniflora e Salicornia fragilis extratos ricos em Polifenóispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/157544/PT
oaire.citation.titleFrontiers in Nutritionpt_PT
oaire.citation.volume8pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameRoberto
person.familyNameTarasco
person.familyNameLaizé
person.familyNameCancela
person.givenNameVânia
person.givenNameMarco
person.givenNameVincent
person.givenNameM. Leonor
person.identifier1230353
person.identifier.ciencia-id681E-40B7-331F
person.identifier.ciencia-id2B1F-0392-9ABE
person.identifier.orcid0000-0002-8134-4045
person.identifier.orcid0000-0001-5894-6526
person.identifier.orcid0000-0001-9565-9198
person.identifier.orcid0000-0003-3114-6662
person.identifier.ridG-9575-2017
person.identifier.ridB-4463-2008
person.identifier.scopus-author-id27467657800
person.identifier.scopus-author-id57194105105
person.identifier.scopus-author-id6602982778
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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