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Maritime halophyte species from southern Portugal as sources of bioactive molecules

2014-04Journal article Open access
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dc.contributor.authorRodrigues, Maria Joao
dc.contributor.authorGangadhar, Katkam N.
dc.contributor.authorVizetto-Duarte, C
dc.contributor.authorWubshet, Sileshi G.
dc.contributor.authorNyberg, Nils T.
dc.contributor.authorBarreira, Luísa
dc.contributor.authorJ. C. or Varela J. or Varela J.C.S., Varela
dc.contributor.authorCustodio, Luisa
dc.date.accessioned2018-12-07T14:52:30Z
dc.date.available2018-12-07T14:52:30Z
dc.date.issued2014-04
dc.description.abstractExtracts of five halophytes from southern Portugal (Arthrocnemum macrostachyum, Mesembryanthemum edule, Juncus acutus, Plantago coronopus and Halimione portulacoides), were studied for antioxidant, anti-inflammatory and in vitro antitumor properties. The most active extracts towards the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical were the methanol extracts of M. edule (IC50 = 0.1 mg/mL) and J. acutus (IC50 = 0.4 mg/mL), and the ether extracts of J. acutus (IC50 = 0.2 mg/mL) and A. macrostachyum (IC50 = 0.3 mg/mL). The highest radical scavenging activity (RSA) against the 2,2-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical was obtained in the ether extract of J. acutus (IC50 = 0.4 mg/mL) and H. portulacoides (IC50 = 0.9 mg/mL). The maximum total phenolic content (TPC) was found in the methanol extract of M. edule (147 mg gallic acid equivalents (GAE)/g) and in the ether extract of J. acutus (94 mg GAE/g). Significant decreases in nitric oxide (NO) production were observed after incubation of macrophages with lipopolysaccharide (LPS) and the chloroform extract of H. portulacoides (IC50 = 109 mu g/mL) and the hexane extract of P. coronopus (IC50 = 98.0 mu g/mL). High in vitro cytotoxic activity and selectivity was obtained with the ether extract of J. acutus. Juncunol was identified as the active compound and for the first time was shown to display selective in vitro cytotoxicity towards various human cancer cells.
dc.description.sponsorshipSEABIOMED project [PTDC/MAR/103957/2008]; XtremeBio project - Foundation for Science and Technology (FCT); Portuguese National Budget; Danish Research Council for Independent Research, Nature and Universe [10-085264]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.3390/md12042228
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.1/11094
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationMarine photosynthetic organisms of the Algarve coast with biomedical applications
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEdulis methanol extract
dc.subjectAntioxidant activity
dc.subjectJuncus-Acutus
dc.subjectArthrocnemum-Macrostachyum
dc.subjectAntimicrobial activities
dc.subjectStaphylococcus-Aureus
dc.subjectPlants
dc.subjectStress
dc.subjectGrowth
dc.subjectCells
dc.titleMaritime halophyte species from southern Portugal as sources of bioactive molecules
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMarine photosynthetic organisms of the Algarve coast with biomedical applications
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMAR%2F103957%2F2008/PT
oaire.citation.endPage2244
oaire.citation.issue4
oaire.citation.startPage2228
oaire.citation.titleMarine Drugs
oaire.citation.volume12
oaire.fundingStream3599-PPCDT
person.familyNameRodrigues
person.familyNameVizetto-Duarte
person.familyNameBarreira
person.familyNameVarela
person.givenNameMaria João
person.givenNameCatarina
person.givenNameLuísa
person.givenNameJoão
person.identifierR-004-VNG
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id6D1A-17E5-1400
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0002-8203-7231
person.identifier.orcid0000-0002-4077-855X
person.identifier.orcid0000-0003-3101-693X
person.identifier.ridM-4223-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id55741416000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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relation.isAuthorOfPublication676ea504-6aef-40d3-9b52-2074b86e1021
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