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Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins

2018Journal article Open access
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dc.contributor.authorMarques, Claudia
dc.contributor.authorFernandes, Iva
dc.contributor.authorMeireles, Manuela
dc.contributor.authorFaria, Ana
dc.contributor.authorSpencer, Jeremy P. E.
dc.contributor.authorMateus, Nuno
dc.contributor.authorCalhau, Conceicao
dc.date.accessioned2018-12-07T14:53:14Z
dc.date.available2018-12-07T14:53:14Z
dc.date.issued2018
dc.description.abstractHigh-fat (HF) diets are thought to disrupt the profile of the gut microbiota in a manner that may contribute to the neuroinflammation and neurobehavioral changes observed in obesity. Accordingly, we hypothesize that by preventing HF-diet induced dysbiosis it is possible to prevent neuroinflammation and the consequent neurological disorders. Anthocyanins are flavonoids found in berries that exhibit anti-neuroinflammatory properties in the context of obesity. Here, we demonstrate that the blackberry anthocyanin-rich extract (BE) can modulate gut microbiota composition and counteract some of the features of HF-diet induced dysbiosis. In addition, we show that the modifications in gut microbial environment are partially linked with the anti-neuroinflammatory properties of BE. Through fecal metabolome analysis, we unravel the mechanism by which BE participates in the bilateral communication between the gut and the brain. BE alters host tryptophan metabolism, increasing the production of the neuroprotective metabolite kynurenic acid. These findings strongly suggest that dietary manipulation of the gut microbiota with anthocyanins can attenuate the neurologic complications of obesity, thus expanding the classification of psychobiotics to anthocyanins.
dc.description.sponsorshipFEDER - Programa Operacional Competitividade e Internacionalizacao - COMPETE2020 [POCI-01-0145-ERDF-007746]; National Funds through FCT - Fundacao para a Ciencia e a Tecnologia within CINTESIS, RD Unit [UID/IC/4255/2013]; [SFRH/BD/93073/2013]; [SFRH/BPD/86173/2012]; [UID/QUI/50006/2013]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1038/s41598-018-29744-5
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.1/11420
dc.language.isoeng
dc.peerreviewedyes
dc.publisherNature Publishing Group
dc.relationSÍNTESE E CARACTERIZAÇÃO ESTRUTURAL DE PIGMENTOS ANTOCIÂNICOS E RESPETIVOS METABOLITOS: BIODISPONIBILIDADE E PROPRIEDADES BIOLÓGICAS.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHigh-fat diet
dc.subjectIntestinal microbiota
dc.subjectInduced obesity
dc.subjectBrain
dc.subjectNeuroinflammation
dc.subjectInflammation
dc.subjectMicroglia
dc.subjectBacteria
dc.subjectPsychobiotics
dc.subjectDysbiosis
dc.titleGut microbiota modulation accounts for the neuroprotective properties of anthocyanins
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSÍNTESE E CARACTERIZAÇÃO ESTRUTURAL DE PIGMENTOS ANTOCIÂNICOS E RESPETIVOS METABOLITOS: BIODISPONIBILIDADE E PROPRIEDADES BIOLÓGICAS.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F86173%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.citation.startPage11341
oaire.citation.titleScientific Reports
oaire.citation.volume8
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
relation.isProjectOfPublicationf722c4be-7105-454b-8f39-af1c0124c7a1
relation.isProjectOfPublication4376b044-9c3b-4073-a23e-76568e5014cf
relation.isProjectOfPublication.latestForDiscovery4376b044-9c3b-4073-a23e-76568e5014cf

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