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Responses of CYP450 dependent system to aliphatic and aromatic hydrocarbons body burden in transplanted mussels from South coast of Portugal

2011Journal article Open access
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dc.contributor.authorLopes, Belisandra
dc.contributor.authorFerreira, A. M.
dc.contributor.authorBebianno, Maria João
dc.date.accessioned2020-04-27T10:28:13Z
dc.date.available2020-04-27T10:28:13Z
dc.date.issued2011
dc.description.abstractMussels Mytilus galloprovincialis were cross-transplanted at South Portugal from a reference site (site 1) to a site more contaminated with hydrocarbon compounds (site 2), and vice versa, in an active biomonitoring (ABM) concept, to assess the biotransformation capacity catalyzed by the mixed function oxygenase (MFO) system. Total alkanes (TAlk), the unresolved complex mixture (UCM), and total polycyclic aromatic hydrocarbons (TPAHs) concentration increased respectively 6, 4.4 and 4.2 fold relatively to control, in mussels transplanted from site 1 to 2. In the cross-transplant, a 48, 57 and 62% depuration of TAlk, UCM and TPAHs concentrations occurred by the end of the 3-4th week. Petrogenic and biogenic (marine and terrigenous) sources of AHs, and petrogenic and pyrolitic (biomass and oil/fuel incomplete combustion) sources of PAHs were detected at both sites. CYP450, CYT b (5) and NADPH-RED in mussels transplanted from site 1 to 2 were induced from day 0 to 28, with a total increase of 35, 32 and 35%, respectively, while biochemical equilibrium to lesser environmental contamination occurs in mussels transplanted from site 2 to 1. A significant relationship between CYP450 and NADPH-RED was found with TPAH, with distinctive behavior at the two sites. MFO system components increase with exposure time at one site and decreases in the other, reflecting an adaptation to distinct environmental hydrocarbon loads. The ABM strategy proved to be useful to understand the environment real impact on the biochemical responses in mussels' local populations. In this study, CYP450 and NADPH-RED are a useful biomarker for hydrocarbon exposure.pt_PT
dc.description.sponsorshipFCT: PRAXIS XXI/BD/3740/94pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s10646-011-0834-7pt_PT
dc.identifier.issn0963-9292
dc.identifier.urihttp://hdl.handle.net/10400.1/13788
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectBiotransformationpt_PT
dc.subjectBody burdenpt_PT
dc.subjectCytochrome P-450 enzyme systempt_PT
dc.subjectCytochromes b5pt_PT
dc.subjectEnvironmental monitoringpt_PT
dc.subjectHydrocarbonspt_PT
dc.subjectMytiluspt_PT
dc.subjectNADPH oxidasespt_PT
dc.subjectPolycyclic aromatic hydrocarbonspt_PT
dc.subjectPortugalpt_PT
dc.subjectSeawaterpt_PT
dc.subjectWater pollutantspt_PT
dc.subjectAlicyclicpt_PT
dc.subjectChemicalpt_PT
dc.titleResponses of CYP450 dependent system to aliphatic and aromatic hydrocarbons body burden in transplanted mussels from South coast of Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage749pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage730pt_PT
oaire.citation.titleEcotoxicologypt_PT
oaire.citation.volume21pt_PT
person.familyNameLopes
person.familyNameBebianno
person.givenNameBelisandra
person.givenNameMaria
person.identifier.ciencia-id6A15-9C84-CA28
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0003-3565-4795
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id23985890600
person.identifier.scopus-author-id7004152715
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication24b957b6-c584-447f-ad53-d6b6aa57d104
relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery24b957b6-c584-447f-ad53-d6b6aa57d104

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