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Ultrasound-assisted extraction as an easy-to-perform analytical methodology for monitoring ibuprofen and its main metabolites in mussels

2022Journal article Open access
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dc.contributor.authorMalvar, José Luis
dc.contributor.authorSantos, Juan Luis
dc.contributor.authorMartín, Julia
dc.contributor.authorAparicio, Irene
dc.contributor.authorFonseca, Tainá
dc.contributor.authorBebianno, Maria
dc.contributor.authorAlonso, Esteban
dc.date.accessioned2022-06-27T14:26:47Z
dc.date.available2022-06-27T14:26:47Z
dc.date.issued2022
dc.description.abstractNon-steroidal anti-infammatory drugs (NSAIDs) have been reported to be the main pharmaceutical class accumulated in seafood. Among them, ibuprofen (IBU) is of special concern as it is used worldwide to treat common pain, does not require a medical prescription, it is often taken in a high daily dose, and has been reported to cause potential adverse efects on aquatic organisms. IBU is highly transformed into hydroxy- and carboxy-metabolites and/or degradation products generated not only after its administration but also during wastewater treatment or in the environment. These compounds can be present in the environment at higher concentrations than IBU and present higher toxicity. In this work, a low-cost and afordable routine analytical method was developed and validated for the frst-time determination of IBU and its main metabolites in mussels. The method is based on ultrasound-assisted extraction (UAE), clean-up by dispersive solid-phase extraction (d-SPE) and analytical determination by liquid chromatography-tandem mass spectrometry. Box-Behnken experimental design was used for method optimisation to better evaluate the infuence and interactions of UAE and d-SPE variables. Extraction recoveries were in the range from 81 to 115%. Precision, expressed as relative standard deviation, was lower than 7%. Method detection limits were in the range from 0.1 to 1.9 ng g−1 dry weight. The method was successfully applied to wild mussels.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s00216-022-04153-wpt_PT
dc.identifier.issn1618-2642
dc.identifier.urihttp://hdl.handle.net/10400.1/17876
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationUID/0350/2020pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectIbuprofenpt_PT
dc.subjectMetabolitespt_PT
dc.subjectMusselspt_PT
dc.subjectUltrasound-assisted extractionpt_PT
dc.subjectDispersive solid-phase extractionpt_PT
dc.subjectLiquid chromatography-tandem mass spectrometrypt_PT
dc.titleUltrasound-assisted extraction as an easy-to-perform analytical methodology for monitoring ibuprofen and its main metabolites in musselspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleAnalytical and Bioanalytical Chemistrypt_PT
person.familyNameGARCIA DA FONSECA
person.familyNameBebianno
person.givenNameTAINÁ
person.givenNameMaria
person.identifier.ciencia-idCC10-4E47-B6DD
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0bacd985-5b3b-4cc8-a31c-774ec234205f
relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery0bacd985-5b3b-4cc8-a31c-774ec234205f

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