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Fine particulate air pollution and occurrence of spontaneous intracerebral hemorrhage in an area of low air pollution

2019-01Journal article Restricted
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dc.contributor.authorNzwalo, HipĂłlito
dc.contributor.authorGuilherme, Patricia
dc.contributor.authorNogueira, Jerina
dc.contributor.authorFelix, Catarina
dc.contributor.authorS. André, Ana
dc.contributor.authorTeles, Joana
dc.contributor.authorMouzinho, Maria
dc.contributor.authorFerreira, Fatima
dc.contributor.authorMarreiros, Ana
dc.contributor.authorLogallo, Nicola
dc.contributor.authorBentes, Carla
dc.date.accessioned2020-07-24T10:53:27Z
dc.date.available2020-07-24T10:53:27Z
dc.date.issued2019-01
dc.description.abstractObjectives:The association between short-term ambient particulate matter ≀ 2.5 ÎŒm diameter (PM2.5) andspontaneous intracerebral hemorrhage (SICH) occurrence is unclear. We aimed to study the association ofambient PM2.5 with occurrence of SICH in an area of low air pollution in southern Portugal.Patientsandmethods:PM2.5 levels from the 3 days before the SICH event (Lag 1, 2, 3) was compared with onecontrol period (Lag 15–17) using a case-crossover analysis. Conditional logistic regression was used to estimatethe odds ratio (OR) with 95% confidence interval (CI). Analysis was stratified by gender, age, functional neu-rological status, type of SICH, environmental factors (temperature, humidity, time of day and season).Results:Three-hundred and eight patients were included (2010–2015); mean age 70.8 years, 62.8% were males.The mean values (ÎŒg/l) of PM2.5 were higher on the case days (Lag1 = 7.76, Lag2 = 7.64, Lag3 = 7.74)compared to control period (Lag14-17 = 6.77). For each 10 ÎŒg/l increase, the likelihood of SICH increased 5.7%(95% CI = 1.020-1.095. P = .002). The strength of the association was higher in patients younger than 70 years(OR = 1.064, 95% CI = 1.009–1.122); without prior to SICH neurological disability (OR = 1.061, 95% CI1.022–1.101); with non-lobar type (OR = 1.054, 95% CI = 1.012–1.099). A circadian and circannual patternwas present with increased strength of the association when SICH occurred in the morning time (OR = 1,067,95% CI = 1.012–1.125), in the fall (OR = 1.118, 95% CI = 1.031–1.213) and the in the winter (OR = 1.064,95% CI = 1.002–1.129). The association was also potentiated at lower temperature values.Conclusion:Short-term increases of PM2.5 are associated with occurrence of SICH in Algarve, a region of lowambient pollution. Patient and ambient level factors can influence the strength of this association.
dc.description.sponsorshipPortuguese Stroke Association
dc.identifier.doi10.1016/j.clineuro.2018.11.022
dc.identifier.issn0303-8467
dc.identifier.issn1872-6968
dc.identifier.urihttp://hdl.handle.net/10400.1/14493
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier Science Bv
dc.subjectEmergency-department visits
dc.subjectShort-term
dc.subjectStroke
dc.subjectRisk
dc.subjectAssociations
dc.subjectExposure
dc.subjectHypertension
dc.subjectMortality
dc.subjectEdmonton
dc.subjectDisease
dc.titleFine particulate air pollution and occurrence of spontaneous intracerebral hemorrhage in an area of low air pollution
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage72
oaire.citation.startPage67
oaire.citation.titleClinical Neurology and Neurosurgery
oaire.citation.volume176
person.familyNameNzwalo
person.familyNameGuilherme
person.familyNameNogueira
person.familyNameSantos André
person.givenNameHipĂłlito
person.givenNamePatricia
person.givenNameJerina
person.givenNameAna Filipa
person.identifier337064
person.identifier.ciencia-id2C1F-E4F3-2C79
person.identifier.ciencia-idD01D-3CF4-D111
person.identifier.ciencia-id511C-998F-DAAD
person.identifier.orcid0000-0002-1502-3534
person.identifier.orcid0000-0002-1388-7822
person.identifier.orcid0000-0001-9349-7594
person.identifier.orcid0000-0002-1916-6401
person.identifier.ridAAG-3931-2020
person.identifier.scopus-author-id36057285600
rcaap.rightsrestrictedAccess
rcaap.typearticle
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relation.isAuthorOfPublication96a41943-f1c3-4ced-b49d-859ccffd6440
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relation.isAuthorOfPublication08f933a3-770f-4dc0-acb6-b6aeba06ab07
relation.isAuthorOfPublication.latestForDiscovery54981fd1-18b8-445d-af14-b3e38d5792b4

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