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Evolution and potential function in molluscs of neuropeptide and receptor homologues of the insect allatostatins

2021-09Journal article Open access
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dc.contributor.authorLi, Zhi
dc.contributor.authorCardoso, João
dc.contributor.authorPeng, Maoxiao
dc.contributor.authorInácio, João P. S.
dc.contributor.authorPower, Deborah
dc.date.accessioned2021-10-29T13:05:01Z
dc.date.available2021-10-29T13:05:01Z
dc.date.issued2021-09
dc.description.abstractThe allatostatins (ASTs), AST-A, AST-B and AST-C, have mainly been investigated in insects. They are a large group of small pleotropic alloregulatory neuropeptides that are unrelated in sequence and activate receptors of the rhodopsin G-protein coupled receptor family (GPCRs). The characteristics and functions of the homologue systems in the molluscs (Buccalin, MIP and AST-C-like), the second most diverse group of protostomes after the arthropods, and of high interest for evolutionary studies due to their less rearranged genomes remains to be explored. In the present study their evolution is deciphered in molluscs and putative functions assigned in bivalves through meta-analysis of transcriptomes and experiments. Homologues of the three arthropod AST-type peptide precursors were identified in molluscs and produce a larger number of mature peptides than in insects. The number of putative receptors were also distinct across mollusc species due to lineage and species-specific duplications. Our evolutionary analysis of the receptors identified for the first time in a mollusc, the cephalopod, GALR-like genes, which challenges the accepted paradigm that AST-AR/buccalin-Rs are the orthologues of vertebrate GALRs in protostomes. Tissue transcriptomes revealed the peptides, and their putative receptors have a widespread distribution in bivalves and in the bivalve Mytilus galloprovincialis, elements of the three peptide-receptor systems are highly abundant in the mantle an innate immune barrier tissue. Exposure of M. galloprovincialis to lipopolysaccharide or a marine pathogenic bacterium, Vibrio harveyi, provoked significant modifications in the expression of genes of the peptide precursor and receptors of the AST-C-like system in the mantle suggesting involvement in the immune response. Overall, our study reveals that homologues of the arthropod AST systems in molluscs are potentially more complex due to the greater number of putative mature peptides and receptor genes. In bivalves they have a broad and varying tissue distribution and abundance, and the elements of the AST-C-like family may have a putative function in the immune response.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fendo.2021.725022pt_PT
dc.identifier.issn1664-2392
dc.identifier.urihttp://hdl.handle.net/10400.1/17264
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Media SApt_PT
dc.relationAlgarve Centre for Marine Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAllatostatinspt_PT
dc.subjectGPCRspt_PT
dc.subjectMolluscspt_PT
dc.subjectImmunitypt_PT
dc.titleEvolution and potential function in molluscs of neuropeptide and receptor homologues of the insect allatostatinspt_PT
dc.title.alternativeEvolução e função potencial em moluscos de neuropeptídeos e receptor homologues das allatostatinas de insetospt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.citation.titleFrontiers in Endocrinologypt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameLi
person.familyNameCardoso
person.familyNamePeng
person.familyNamePower
person.givenNameZhi
person.givenNameJoão
person.givenNameMaoxiao
person.givenNameDeborah Mary
person.identifier14332
person.identifier.ciencia-id361E-ECE9-BC00
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-id0A1D-96B9-27EB
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-4255-4170
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0002-4855-1202
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-4151-2013
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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