Sapientia
UAlg Scientific Repository
About Sapientia
SAPIENTIA brings together all scientific publications produced by teachers, researchers, and students (theses and dissertations) from the University of Algarve and cooperating entities (ULSALG-Unidade Local de Saúde do Algarve and Ciência Viva network centers in the Algarve) and aims to maximize their visibility, ensure easy access to this collection, improve the public impact of the scientific activity of the University and other entities, as well as ensure the preservation of their memories.
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Recent Submissions
Unraveling the potential of gasotransmitters as neurogenic and neuroprotective molecules: focus on Alzheimer's and Parkinson's diseases.
Publication . Simao, Sonia; Filipa Santos, Daniela; Teixeira, Mariana; Ribeiro Agostinho, Rafaela; Rodrigues, Joana; Vitorino, Marta; Pombinho de Araújo, Inês Maria
Alzheimer's disease and Parkinson's disease are the two most prevalent neurodegenerative disorders worldwide, both characterized by progressive neuronal loss. Despite distinct pathophysiological features, they share cellular dysfunctions such as abnormal protein aggregation, oxidative stress, and neuroinflammation, research into which might be beneficial for developing novel therapeutic strategies that could tackle both conditions. This review highlights the emerging role of the gasotransmitters nitric oxide, carbon monoxide and hydrogen sulfide as modulators of adult neurogenesis and neuroprotection in Alzheimer's disease and Parkinson's disease. We have gathered recent evidence demonstrating that these endogenous gases exert anti-inflammatory, antioxidant, and anti-apoptotic effects, and, critically, promote neurogenesis - suggesting a dual neuroprotective and neuroregenerative therapeutic potential. The unique physicochemical features of these gasotransmitters, including their ability to cross the blood-brain barrier and diffuse rapidly throughout the neural tissue, further support their suitability as candidates for innovative neuroregenerative treatments. While clinical translation remains challenging, harnessing the neurogenic and neuroprotective actions of these gasotransmitters may offer transformative avenues for addressing the increasing burden of Alzheimer's disease and Parkinson's disease.
Seasonal, spatial, and high-frequency monitoring of dissolved oxygen and net ecosystem metabolism in a shallow coastal lagoon, Ria Formosa – Portugal
Publication . Correia, Cátia; Jacob, José; Cravo, Alexandra
This study provides a detailed assessment of dissolved oxygen (DO) dynamics and net ecosystem metabolism (NEM) in the Ria Formosa coastal lagoon, highlighting how spatial and temporal variability shape mesotidal ecosystems. Complementary approaches were applied: short-term (24 h) diel oxygen open-water method at two stations (eastern and western boundaries) in comparison with the bottle incubation method, and a 2.5-year high-frequency dataset at an inner station lagoon. DO showed clear seasonal patterns, largely driven by photosynthesis and respiration, but strongly modulated by water circulation and hydrodynamics. Sporadic hypoxic events (DO ≤ 2 mg L−1) were observed but do not represent a risk. The boundary stations are shallower and colonized by submerged vegetation, displayed stronger diel fluctuations than at the inner station, underscoring the role of biological processes in lagoon metabolism. NEM estimates revealed strong spatial contrasts: the western station was autotrophic, while the eastern station predominantly attributed to restricted water exchange. Long-term records from the inner station indicated a slightly heterotrophic status, reinforcing the value of sustained high-frequency monitoring for capturing ecosystem trends overlooked by short-term approaches. The results also highlight lagoon–coastal ocean connectivity, suggesting dual exchanges: local production may be exported offshore to sustain adjacent coastal areas, while coastal processes, such as upwelling, can also influence lagoon metabolism. Methodological comparisons confirmed that bottle incubation method underestimated NEM relative to diel oxygen open-water method, emphasizing the role of hydrodynamics in mesotidal system metabolism. Although sampling focused on western and eastern boundaries and inner lagoon, the strong tidal renewal in the main and secondary channels suggests Ria Formosa overall is close to metabolic balance, with spatial heterogeneity shaped by hydrodynamics, vegetation, and coastal forcing. By integrating short-term, high-frequency, and long-term observations, this study advances understanding of metabolism in coastal lagoons, offering key insights for predicting ecosystem responses to climate change and for guiding management of vulnerable coastal environments.
The interplay of personality traits and early life experiences in predicting delinquent behaviors
Publication . Bonfá-Araujo, Bruno; Baptista, Makilim Nunes; Pechorro, Pedro; Maroco, João; Franco, Víthor Rosa; Nunes, Cristina; Jonason, Peter K.
This study explores the interplay between family bonds, attachment styles, emotional regulation, dark personality traits, and delinquent behaviors. We assessed 336 Brazilians (M = 24.61, SD = 8.30), using network analysis. Participants were assessed using the Proposed Specifiers for Conduct Disorder, Parental Bonding Instrument, Difficulties in Emotion Regulation Scale, The Brazilian Adult Attachment Scale, The Short Dark Tetrad, and the Self-Report Delinquency Scale. Our findings suggest that attachment and family bonds influence emotional regulation, affecting delinquent behaviors. Dark personality traits are strong predictors of delinquent behaviors. We highlight the importance of early life experiences and personality in understanding delinquent and antisocial behaviors.
Tides of change for a sustainable blue economy: a systematic literature review of innovation in maritime activities
Publication . Elston, Jennifer Nicole; Pinto, Hugo; Nogueira, Carla
Abstract: The Blue Economy, a dynamic field intertwining ocean sustainability, innovation, and economic progress, stands as a beacon of hope for fostering inclusive growth while advancing sustainable practices. This systematic literature review embarks on a journey to unravel the intricate relationship between innovation and sustainable practices within the Blue Economy, to uncover how innovation transforms and promotes sustainability, and to pinpoint barriers to adoption of innovative technologies and processes. By delving into the multifaceted landscape of sustainability and innovation studies within the Blue Economy, this study illuminates the potential of innovative approaches to drive sustainability in coastal and marine areas. With global attention shifting toward ocean sustainability due to survival risks and resource scarcity, this study addresses two central questions: how does innovation drive sustainable practices within the Blue Economy, and what barriers prevent the widespread adoption of these innovations? Using this interrogation as a compass to navigate the existing literature, and through a comprehensive analysis of the role of innovation in promoting sustainable practices, this review aims to provide hints for the main directions for a sustainable Blue Economy.
Matrix solid-phase dispersion procedure for determination of antibiotics and metabolites in mussels: application in exposure bioassays
Publication . Mejías, Carmen; GARCIA DA FONSECA, TAINÁ; García-Criado, Noelia; Martín, Julia; Santos, Juan Luis; Aparicio, Irene; Alonso, Esteban
Abstract: The presence of antibiotics in seafood for human consumption may pose a risk for consumers. Furthermore, some marine organisms, such as mussels, can result in appropriate bioindicators of marine contamination. In this work, a multiresidue analytical methodology suitable for the determination of antibiotics and metabolites in mussels is proposed. The target compounds include three sulphonamides and trimethoprim (TMP) and six of their main metabolites. Sample treatment involves extraction and clean-up in a single step using matrix solid-phase dispersion with acetonitrile. Analytical determination was carried out by liquid chromatography–tandem mass spectrometry. Good linearity (R2 > 0.99), accuracy (from 80.8 to 118%), and limits of quantification (lower than 5 ng g−1 (dry matter, dm)) were obtained for all selected compounds. The method was applied to the determination of antibiotics in mussel samples from an exposure assay with contaminated seawater with TMP and sulfamethoxazole (SMX). Both antibiotics were detected in the analysed samples with concentrations up to 77.5 ng g−1 dm. TMP was bioconcentrated to a higher extent than SMX, attributable to its higher hydrophobicity. None of the metabolites were detected. These results demonstrate that Mytilus galloprovincialis is a suitable bioindicator to assess marine pollution.