CCM4-Vários
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Browsing CCM4-Vários by Author "Cancela, Leonor"
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- Skeletal development and bone-related gene expression in fish larvaePublication . Gavaia, Paulo J.; Cancela, LeonorThe fish skeleton; skeletal malformations; skeletal malformations in mediterranean species; Types of skeletal malformations; Senegal sole skeletal development; Senegal sole skeletal deformities; Skeletal development in Danio rerio; ALP and TRAP in skeletal development; Skeletal development in Pagrus auriga; Time course of skeletal development in Pagrus auriga; Spatio-temporal pattern of bgp expression; bgp / mgp expression during development; In situ localization of zebrafish bgp mRNA;In situ localization of sole bgp mRNA; Immuno-detection of Bgp accumulation in zebrafish; Immuno-detection of Bgp accumulation in sole P.; In situ localization of zebrafish and sole mgp mRNA; Immuno-detection of MGP accumulation in zebrafish; Summary of zebrafish skeletogenesis; Summary of Senegal sole skeletogenesis; In situ localization of zebrafish CollX1 mRNA;
- Warfarin effects in the skeletal development of zebrafish (Danio rerio)Publication . Peres dos Santos, R.; Bensimon-Brito, A.; Gavaia, Paulo J.; Cancela, LeonorVitamin K-dependent gamma carboxylation (VKGC) is crucial for posttranslational modification of glutamate residues to form α-carboxy glutamic acid (Gla) in the presence of reduced vitamin K, molecular oxygen, and carbon dioxide (1). This modification has important implications, mainly physiological, like homeostasis, signal transduction and bone calcification. This mechanism ensures complete carboxylation of coagulation factors, and proteins like bone Gla protein (BGP) and matrix Gla protein (MGP), being essential for their biological activity. Warfarin is a known anticoagulant that inhibits the action of VKGC (2), inhibiting consequently the activity of the referred proteins.