Browsing by Author "Abreu, Pedro"
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- Intracerebral hemorrhage as a manifestation of cerebral hyperperfusion syndrome after carotid revascularization: systematic review and meta-analysisPublication . Abreu, Pedro; Nogueira, Jerina; Rodrigues, Filipe Brogueira; Nascimento, Ana; Carvalho, Mariana; Marreiros, Ana; Nzwalo, HipólitoIntracerebral hemorrhage (ICH) in the context of cerebral hyperperfusion syndrome (CHS) is an uncommon but potentially lethal complication after carotid revascularization for carotid occlusive disease. Information about its incidence, risk factors and fatality is scarce. Therefore, we aimed to perform a systematic review and meta-analysis focusing on the incidence, risk factors and outcomes of ICH in the context of CHS after carotid revascularization. We searched the PubMed and EBSCO hosts for all studies published in English about CHS in the context of carotid revascularization. Two reviewers independently assessed each study for eligibility based on predefined criteria. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, and the PROSPERO register was made (register no. CRD42016033190), including the pre-specified protocol. Forty-one studies involving 28,956 participants were deemed eligible and included in our analysis. The overall quality of the included studies was fair. The pooled frequency of ICH in the context of CHS was 38% (95% CI: 26% to 51%, I2 = 84%, 24 studies), and the pooled case fatality of ICH after CHS was 51% (95% CI: 32% to 71%, I2 = 77%, 17 studies). When comparing carotid angioplasty with stenting (CAS) with carotid endarterectomy (CEA), post-procedural ICH in the context of CHS was less frequent in CEA. ICH following CHS occurred less often in large series and was rare in asymptomatic patients. The most common risk factors were periprocedural hypertension and ipsilateral severe stenosis. ICH as a manifestation of CHS is rare, more frequent after CAS and associated with poor prognosis. Periprocedural control of hypertension can reduce its occurrence.
- Natural history of relapsing remitting multiple sclerosis in a long-lasting cohort from a tertiary MS centre in PortugalPublication . Sá, Maria José; Sequeira, Lucinda; Ferro, Daniela; Marcolino, Adilson; Rocha, Ana Luísa; Seabra, Mafalda; Mendonça, Teresa; Abreu, Pedro; Guimarães, Joana; Macedo, AnaBackground: Several disease-modifying therapies (DMTs) have emerged in the last two decades for the treatment of multiple sclerosis (MS). The increasing use of these therapies has enhanced the need to study its impact on long-term disease progression and on the natural history of MS. This study aimed to characterize a Portuguese MS patient cohort in what concerns the natural history of disease by exploring differences throughout 3 decades. Methods: Longitudinal, retrospective, non-interventional study. Patients aged >= 18 years old, with confirmed diagnosis of relapsing-remitting MS (RRMS), were included. Biodemographic and clinical characteristics (MS diagnosis, patient follow-up, relapses, treatment, and exams) were assessed and compared according to the first appointment date throughout 10-year spans (1987-1996; 1997-2006; 2007-2016). Results: 548 patients were included in this analysis. Significant differences were observed between decades for evoked potential (EP) and cerebrospinal fluid (CSF) exams conducted at diagnosis, the first with less expression on the last decade; the median number of relapses per year (higher in the subgroup 07-16); EDSS at baseline and at last appointment (both higher in the subgroup 87-96); and the percentage of patients achieving EDSS 3.0 and EDSS 6.0 (increased in the subgroup 87-96). Additionally, time from diagnosis to first treatment was significantly lower in patients from the most recent decade, and a greater percentage of such patients, compared to the other two subgroups, was, at last appointment, under a second line DMT. Conclusion: In general, our study reflects findings from longitudinal studies on MS progression already published in the literature. In recent years, the growing number of more effective DMTs, along with earlier disease detection, and improvements in access to healthcare appear to have had a positive impact on patients' access to treatment and, consequently, disease progression. Additional studies, with increased follow up time, are needed to further investigate the effect of treatment improvement in the natural history of MS.
- A pioneering longterm experiment on mesophotic macrofouling communities in the North AtlanticPublication . Canning-Clode, João; Gizzi, Francesca; Braga-Henriques, Andreia; Ramalhosa, Patrício; Abreu, Pedro; Álvarez, Soledad; Biscoito, Manuel; Buhl-Mortensen, Pål; Delgado, João; Esson, Diane; Freitas, Mafalda; Freitas, Magno; Henriques, Filipe; Jakobsen, Joachim; Jakobsen, Kirsten; Kerckhof, Francis; Lüter, Carsten; Moura, Carlos J.; Radeta, Marko; Rocha, Rosana M.; Santos, Romana; Sepúlveda, Pedro; Silva, Rodrigo; Silva, Teresa; Souto, Javier; Triay-Portella, Raül; Wirtz, Peter; Xavier, Joana R.; Bastida-Zavala, Rolando; Bellou, Nikoleta; Gueroun, Sonia K. M.; Monteiro, João G.The mesophotic zone represents one of our planet's largest and least explored biomes. An increasing number of studies evidence the importance of macrofouling species in marine ecosystems, but information on these communities and the factors influencing their structures at mesophotic depths remain poor. This lack of understanding limits our ability to predict anthropogenic impacts or conduct restoration operations in the mesophotic and the lower boundary of the euphotic zones. In this study, we performed a 24-month experiment in a natural environment to investigate three factors influencing the macrobenthic community structure of the mesophotic and the euphotic lower boundary: depth, substrate orientation and substrate material. Using a manned submersible, several recruitment panels of two different materials were deployed at 100, 200 and 400 meters in vertical and horizontal positions. All three factors contributed to structuring the macrofouling communities, but depth and substrate orientation displayed the strongest effects. This study not only advances our understanding of lower boundary euphotic and mesophotic macrofouling communities but also establishes a foundation for future research and restoration efforts of mesophotic environments in the Madeira archipelago, where mesophotic habitats are amongst the least studied marine habitats in the Northeast Atlantic.
- Widely scalable mobile underwater sonar technology: an overview of the H2020 WiMUST projectPublication . Abreu, Pedro; Antonelli, Gianluca; Arrichiello, Filippo; Caffaz, Andrea; Caiti, Andrea; Casalino, Giuseppe; Volpi, Nicola Catenacci; de Jong, Ivan Bielic; De Palma, Daniela; Duarte, Henrique; Gomes, Joao Pedro; Grimsdale, Jonathan; Indiveri, Giovanni; Jesus, S. M.; Kebkal, Konstantin; Kelholt, Elbert; Pascoal, Antonio; Polani, Daniel; Pollini, Lorenzo; Simetti, Enrico; Turetta, AlessioThe Widely scalable Mobile Underwater Sonar Technology (WIMUST) project is an H2020 Research and Innovation Action funded by European Commission. The project aims at developing a system of cooperative autonomous underwater vehicles (AUVs) for geotechnical surveying and geophysical exploration. The paper describes the main objectives of the project, given an overview of the methodologies adopted to achieve them, and summarizes the work done in the first year of R&D work.