Browsing by Author "Authier, Tatiana"
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- Applications of polyoxometalates in medicine and their putative mechanisms of actionPublication . Authier, Tatiana; Aureliano, M.Polyoxometalates (POMs) are inorganic metal-oxide assemblies presenting a wide range of possible structure, size and metal-combination, as well as a high solubility in water and large redox chemistry. These properties are of a great interest in medicine and polyoxometalates are investigated to produce inorganic-drugs against virus, bacteria and tumour cells. Results showed that POMs, such as the PM-8 ([NH3Pr]6[Mo7O24]•3H2O) induced inhibition of tumour cell proliferation, whereas others POMs inhibit DNA- or RNA-virus activation or bacterial growth. While the mechanisms of action of the anti-viral and –bacterial activities are quite well understood, the same does not go for the anti-tumour activity. Nevertheless, the inhibition of tumour proliferation seems to be correlated with the inhibition of certain enzymes such as histone deacetylases and ecto-nucleotidases, or with the programmed death, apoptosis. In this report, these several hypothesis were approach, in a way to explain the anti-tumour, -bacterial and -viral activities of some polyoxometales, but nothing as yet been concluded and further studies are needed for a better understading.